Renal parenchymal thickness in children with solitary functioning kidney

Flögelová, Hana; Langer, J; Šmakal, Oldřich; Michálková, Kamila; Bakaj-Zbrožková, Lenka; Zapletalová, Jana

doi:10.1007/s00467-013-2610-9

Cited by 6 publications

(2 citation statements)

References 34 publications

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“…Using a long-term follow-up protocol, we evaluated a cohort of patients followed at our center between 2000 and 2023 for a congenital SFK caused by URA or UMCDK. Some of these patients (46 out of 160) had been enrolled in our earlier prospective multicenter study entitled Renal Parenchymal Thickness in Children with Solitary Functioning Kidney [9]. The current cohort of patients included all children with URA or UMCDK identi ed by prenatal or postnatal US screening.…”

Section: Patientsmentioning

confidence: 99%

Early Diagnosis of Solitary Functioning Kidney: Comparing the Prognosis of Renal Agenesis and Multicystic Dysplastic Kidney

Flögelova,

Bouchalova,

Smakal

et al. 2023

Preprint

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Background Individuals with congenital solitary functioning kidney (SFK) are at an increased risk of kidney damage. According to some studies, the risk is higher in unilateral renal agenesis (URA) than in unilateral multicystic dysplastic kidney (UMCDK). We hypothesized that with early detection of children with URA and UMCDK, there would be no difference in the presence of hypertension, proteinuria, and reduced glomerular filtration rate (GFR) between URA and UMCDK. Methods Based on a long-term follow-up protocol, we evaluated a cohort of 160 children followed from birth for SFK (84 with URA and 76 with UMCDK) detected by prenatal or routine neonatal ultrasound screening. Hypertension, proteinuria and elevated GFR were monitored as markers of kidney damage. We compared the characteristics and outcomes of the subgroups of children with URA and UMCDK. Results GFR was reduced in 42 (26.2%) children, of whom 41 showed only mild reduction. Hypertension and proteinuria were found in 22 (13.8%) and 14 (8.8%) children, respectively. Combined kidney damage was present in 57 (35.6%) children. The UMCDK and URA subgroups differed in GFR at final examination, with UMCDK patients being significantly more likely to have normal GFR compared to URA patients (82% vs 67%; p = 0.039). Conclusions One third of the children showed signs of SFK damage, albeit mild. Patients with URA had reduced GFR significantly more often than those with UMCDK, but did not differ in the rates of hyperfiltration injury or congenital anomalies of the kidneys and urinary tract (CAKUT) in SFK.

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Section: Patientsmentioning

confidence: 99%

Early Diagnosis of Solitary Functioning Kidney: Comparing the Prognosis of Renal Agenesis and Multicystic Dysplastic Kidney

Flögelova,

Bouchalova,

Smakal

et al. 2023

Preprint

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“…Most solitary kidneys in children are of congenital origin, with renal agenesis accounting for one in every 1000–2000 births [ 1 ]. In general, congenital solitary kidney is more common in boys [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of reflux nephropathy in Iranian children with solitary kidney: results of a multi-center study

et al. 2022

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Background Given the importance of the function of the remnant kidney in children with unilateral renal agenesis and the significance of timely diagnosis and treatment of reflux nephropathy to prevent further damage to the remaining kidney, we aimed to determine the prevalence of reflux nephropathy in this subgroup of pediatric patients. Methods In general, 274 children referred to pediatric nephrologists in different parts of Iran were evaluated, of whom 199 had solitary kidney and were included in this cross-sectional study. The reasons for referral included urinary tract infection (UTI), abnormal renal ultrasonography, being symptomatic, and incidental screening. Demographic characteristics, including age and gender were recorded. History of UTI and presence of vesicoureteral reflux (VUR) were evaluated. Results Of the 274 children evaluated in this study with the mean age (SD) of 4.71 (4.24) years, 199 (72.6%) had solitary kidney. Among these, 118 (59.3%) were male and 81 (60.7%) were female, 21.1% had a history of UTI, and VUR was present in 23.1%. The most common cause of referral was abnormal renal ultrasonography (40.2%), followed by incidental screening (21.1%), being symptomatic (14.1%), and UTI (5.5%). In 116 children (58.3%), the right kidneys and in 83 (41.7%) the left kidneys were absent. Besides, 14.6% of the participants had consanguineous parents and 3% had a family history of solitary kidney. Upon DMSA scan, the single kidney was scarred in 13.1%, of which only 7.5% were associated with VUR. In addition, proteinuria and hematuria were observed in 6.5% and 1.5% of children, respectively. Conclusions The prevalence of reflux nephropathy was 7.5% in children with solitary kidney with a male predominance. Given the relatively high prevalence of reflux nephropathy in these children, screening for VUR in the remnant kidney appears to be essential in this population.

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Towards adulthood with a solitary kidney

et al. 2018

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Renal parenchymal thickness in children with solitary functioning kidney

Abstract: Based on our results, we suggest that PT in the SFK is correlated with height, weight and age of the patient. Consequently, measurements of PT may be used for monitoring the development of the healthy SFK and may contribute to a more accurate assessment of the severity of SFK anomalies.

Cited by 6 publications

References 34 publications

Early Diagnosis of Solitary Functioning Kidney: Comparing the Prognosis of Renal Agenesis and Multicystic Dysplastic Kidney

Early Diagnosis of Solitary Functioning Kidney: Comparing the Prognosis of Renal Agenesis and Multicystic Dysplastic Kidney

Prevalence of reflux nephropathy in Iranian children with solitary kidney: results of a multi-center study

Towards adulthood with a solitary kidney

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