Renal Paraganglioma: Report of a Case Managed by Robotic Assisted Laparoscopic Partial Nephrectomy and Review of the Literature

Bahar, Burhanuddin; Pambuccian, Stefan E.; Gupta, Gopal N.; Barkan, Güliz A.

doi:10.1155/2014/527592

Cited by 5 publications

(8 citation statements)

References 16 publications

(20 reference statements)

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“…However, metastatic lesions would have also been expected elsewhere within the abdomen so the latter explanation is less likely. Renal paragangliomas can be difficult to distinguish clinically and histologically from renal cell carcinoma (Bahar et al 2014 ), as was evident in this case following initial routine histopathology before the employment of additional immunohistochemical stains and TEM. Immunohistochemistry, although very useful in differentiating tumours of neuroendocrine origin, may not be helpful to diagnose malignant undifferentiated neoplasms; therefore, additional diagnostic modalities such as TEM are warranted (Rizzo et al 2008 ).…”

Section: Discussionmentioning

confidence: 85%

“…Primary neuroendocrine tumours of the kidney are rare and are frequently incorrectly diagnosed as other renal tumours such as renal cell carcinoma, mesonephric tumours or undifferentiated carcinoma (Aung et al 2013 ). Renal paragangliomas are thought to arise from ectopic adrenal tissue or adrenal remnants located within the kidney (Bahar et al 2014 ). In the present case report, the renal paragangliomas could have arisen from ectopic adrenal tissue within each kidney or as a result of metastasis from one kidney to the other.…”

Section: Discussionmentioning

confidence: 99%

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The diagnosis of bilateral primary renal paragangliomas in a cat

Friedlein¹,

Carter²,

Last³

et al. 2017

Journal of the South African Veterinary Association

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A 9-year-old sterilised female domestic short-hair cat was referred with a history of vomiting and anorexia of 3 months’ duration. Biochemistry, full-blood counts, thoracic radiographs, feline pancreatic-specific lipase, abdominal ultrasonography and feline immunodeficiency virus/feline leukaemia virus (FIV/FeLV) SNAP tests had been performed. Mild hypochloraemia and moderate hypokalaemia were evident on initial presentation. Abdominal ultrasonography initially revealed unilateral renal nodules on the left side. These were subjected to fine-needle aspiration and cytological evaluation. A neuroendocrine tumour was suspected, and biopsies via midline coeliotomy were taken to confirm the diagnosis. Initial histopathology diagnosed primary renal carcinomas or neuroendocrine neoplasia; however, the definitive diagnosis became renal paragangliomas after immunohistochemistry and transmission electron microscopy were performed. The cat was regularly monitored with serum biochemistry parameters, blood pressure determinations, thoracic radiographs and subsequent abdominal ultrasonography. Biochemistry, radiography and blood pressures remained normal over a 24-week follow-up period, while subsequent ultrasonography revealed tumour progression in both number and size in both kidneys. Primary neuroendocrine tumours of the kidney are frequently incorrectly diagnosed as other renal tumours such as renal cell carcinoma, mesonephric tumours or undifferentiated carcinomas. This case report highlights the importance of additional testing, including immunohistochemistry and transmission electron microscopy, to obtain a definitive diagnosis of paragangliomas.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

The diagnosis of bilateral primary renal paragangliomas in a cat

Friedlein¹,

Carter²,

Last³

et al. 2017

Journal of the South African Veterinary Association

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“…Ezgi Işıl Turhan, et al: Pigmented Renal Paraganglioma as palpitation, sweating, and headache related to hormone secretion [14].…”

Section: Apjccwaocpcommentioning

confidence: 99%

“…According to histochemical studies and electron microscopic findings, this pigment is neuromelanin, lipofuskin or true melanin [3]. Neuromelanin has been reported in some pigmented paraganglioma cases [12][13][14][15][16][17][18]. Melanin was reported in an article published by Tavassoli in 1986 [5].…”

Section: Apjccwaocpcommentioning

confidence: 99%

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Pigmented Renal Paraganglioma: A Case Report and Review of the Literature

Turhan

Saraydaroğlu

Yavaşçaoğlu

2020

Asian Pac J Cancer Care

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Aim: Paragangliomas are rare non-epithelial tumors originating from paraganglia cells in various anatomical regions. Pigmented paragangliomas are more rare. We present the second reported case of kidney-induced pigmented paraganglioma in conjunction with literature. Case Report: A 44-year-old female patient with no known systemic disease was evaluated due to palpitations and a mass detected in the right kidney. Surgically, a 6 cm mass localized between kidney middle pol and vena cava inferior was separated from the surrounding tissues. In the sections prepared from the lesion, there were organoid patterned cell islands separated by fibrovascular septa. Brown pigment was evident in most of the tumor cells. Immunohistochemically, tumor cells expressed synaptophysin, chromogranine, NSE. In tumor cells, Mart1 and HMB45 were negative. In the light of all these findings, the case was diagnosed as ‘pigmented paraganglioma’. Discussion: The most common localizations of paragangliomas are carotid body, vagal body, middle ear, Zuckerkandl organ, mediastinum and retroperitoneum. There are 12 cases of intrarenal paraganglioma reported in the literature. Pigmented paraganglioma originating from the kidney has been reported only once. Conclusions: By presenting the second kidney-derived pigmented paraganglioma reported in the literature, we emphasize that the morphological and geographic spectra of these tumors may be large.

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Spontaneous Retroperitoneal Bleeding as a Complication of Unusual Renal Paraganglioma

Sangey¹,

Rusheke

Sangey

et al. 2022

Case Reports in Nephrology

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Spontaneous retroperitoneal bleeding is a rare occurrence that might have catastrophic implications. We present a 58-year-old male with a 4-day history of progressively worsening left-sided flank pain due to retroperitoneal hemorrhage from a nonfunctional renal paraganglioma. Abdominal contrast CT scan was helpful in locating the tumor, estimating tumor size and extent of bleeding, visualizing the interaction between the tumor and the surroundings, and ruling out any potential metastasis; however, it lacked specificity in identifying the origin of the mass, needing histologic investigation for a conclusive diagnosis. MRI was not available at our center. We report a rare case of spontaneous retroperitoneal bleeding as a complication of an unusual nonfunctional renal paraganglioma, which was initially misdiagnosed as renal cell carcinoma but later confirmed by postoperative histopathology.

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Renal Paraganglioma: Report of a Case Managed by Robotic Assisted Laparoscopic Partial Nephrectomy and Review of the Literature

Abstract: We describe the pathological and clinical presentation of a rare case of renal paraganglioma occurring as an incidental left renal mass in a 58-year-old woman. The patient underwent robotic assisted laparoscopic partial nephrectomy, which is the first one in the literature.

Cited by 5 publications

References 16 publications

The diagnosis of bilateral primary renal paragangliomas in a cat

The diagnosis of bilateral primary renal paragangliomas in a cat

Pigmented Renal Paraganglioma: A Case Report and Review of the Literature

Spontaneous Retroperitoneal Bleeding as a Complication of Unusual Renal Paraganglioma

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