Renal Oxygenation Measurement During Partial Nephrectomy Using Hyperspectral Imaging May Predict Acute Postoperative Renal Function

Abstract

Baseline renal oxygenation, as measured with HsI, may help predict risk of postoperative renal insufficiency and may distinguish between patients with otherwise similar baseline characteristics, such as eGFR. HsI may provide individualized assessment of renal function to influence intraoperative decision-making to help preserve renal function.

Intraoperative multispectral and hyperspectral label‐free imaging: A systematic review of in vivo clinical studies

“…Fourteen studies satisfied the inclusion criteria and underwent qualitative analysis (Table ). Eight different multispectral or HSI systems have been used in human surgical studies including four studies reporting use of a digital light processing (DLP) HSI system in renal surgery and four studies from the collaborative European HELICoiD (HypErspectraL Imaging Cancer Detection) project . Studies comprised either individual case reports or case series involving four to 37 patients .…”

“…To date, HSI has only been used for intraoperative tumour detection in brain tumour surgery whereas a variety of different surgeries have used HSI to assess tissue perfusion and oxygenation; including, an assessment of reconstructive skin flaps in breast and oral cancer surgery, to assess renal oxygenation during partial nephrectomy , and to assess brain perfusion within the epileptogenic zone during epilepsy surgery and following cerebrovascular anastomosis .…”

“…The reported HSI systems used either a wavelength scanning , line‐scanning or snapshot mosaic acquisition mode. Two systems imaged a selection of discrete wavelengths , whereas the remainder preferred to image a spectral range with 0.4 to 5 nm wavelength steps.…”

“…A wide spectral wavelength range was employed by the HELICoiD group for the purposes of tumour detection (400‐1700 nm) whereas a narrower spectrum was used in studies generating an intraoperative tissue oxygenation map. A very narrow wavelength range of 520 to 645 nm used by the Dallas group but other HSI oxygenation studies included the infrared wavelength spectrum.…”

“…Their work demonstrated that oxygenation maps can successfully characterize the dynamic changes in renal perfusion observed during surgery. It also showed that intraoperatively acquired HSI data may be used as an independent predictor of post‐operative renal function .…”