Renal oncocytoma with t(5;12;11), der(1)t(1;8) and add(19): “true” oncocytoma or chromophobe adenoma?

Dijkhuizen, Trijnie; Berg, Eva van den; Störkel, Stephan; Vries, L.B.A. de; Veen, Anneke Y. van der; Wilbrink, M.J.M.; Kessel, A.H.M. Geurts van; Jong, Bauke M. de

doi:10.1002/(sici)1097-0215(19971114)73:4<521::aid-ijc11>3.0.co;2-c

Cited by 31 publications

(10 citation statements)

References 24 publications

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“…The rationale to group these two kinds of tumors is the emerging evidence that both entities may be in fact related from the histogenetic standpoint. Both chromophobe renal-cell carcinomas and renal oncocytomas are derived from the intercalated cells of the collecting ducts (62,63); share some cytogenetic abnormalities (64); have overlapping morphologic (65,66), immunohistochemical (67), and ultrastructural (68) features; and occur in cases of renal oncocytosis (69). Similarly, in the previously reported cases in the literature of coexisting angiomyolipomas and renal-cell neoplasia, an unusually high incidence of oncocytomas associated with angiomyolipoma is also seen (12%).…”

Section: Discussionmentioning

confidence: 99%

Concurrent Angiomyolipoma and Renal Cell Neoplasia: A Study of 36 Cases

et al. 2001

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Little is known about the association of angiomyolipoma and adult renal-cell neoplasia. We studied the clinicopathologic features of 36 patients with concurrent angiomyolipoma and renal-cell neoplasia from the consultation and surgical pathology files of nine institutions. HMB-45 immunoreactivity was analyzed in both neoplasms. Twenty-five sporadic cases of patients with angiomyolipoma and renal-cell neoplasia and 11 cases of patients with tuberous sclerosis, as defined by Gomez' criteria, had mean ages of 59 and 53 years, respectively, and female-male ratios of 2:1 and 5:1, respectively. The mean size of the angiomyolipomas was 1 cm in the sporadic cases and 3 cm in those patients with tuberous sclerosis (medians: 0.5 and 3 cm, respectively, P ‫؍‬ .002). The mean sizes of the renal-cell neoplasms were 5 cm in sporadic cases and 6 cm in patients with tuberous sclerosis (medians: 4 and 5 cm, respectively; P ‫؍‬ .88). In both clinical settings, angiomyolipoma was more commonly the incidental tumor. Clear-cell (conventional) renal-cell carcinoma was the most common renal-cell neoplasm in both groups of patients, accounting for approximately two thirds of the tumors. In patients with tuberous sclerosis, 27% of renal-cell neoplasms were oncocytomas, compared with 8% in sporadic cases (P ‫؍‬ .15). Papillary neoplasia, chromophobe, and collecting-duct renal-cell carcinoma were found only in sporadic cases. All of the 22 renal-cell neoplasms studied were negative for HMB-45, whereas all 25 angiomyolipomas studied were positive.

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Section: Discussionmentioning

confidence: 99%

Concurrent Angiomyolipoma and Renal Cell Neoplasia: A Study of 36 Cases

et al. 2001

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“…Cytogenetic studies of oncocytomas have delineated two main subcategories: rearrangements involving chromosomal region 11q13 [Walter et al, 1989; Fuzesi et al, 1994, 1998; Dijkhuizen et al, 1997; Neuhaus et al, 1997; Sinke et al, 1997] and combined loss of chromosomes 1 and X/Y [Crotty et al, 1992; Meloni et al, 1992b; Brown et al, 1996; Thrash‐Bingham et al, 1996; Dal Cin et al, 2000; Feder et al, 2000]. Molecular studies have confirmed that, in the case of chromosome 1, the loss involves 1p rather than the whole chromosome [Thrash‐Bingham et al, 1996; Dal Cin et al, 2000], suggesting that a possible tumor suppressor gene may be located at this region.…”

Section: Clinical Cytogenetic and Molecular Characteristics Of Renal mentioning

confidence: 99%

Renal cancer: Cytogenetic and molecular genetic aspects

Meloni‐Ehrig

2002

Am. J. Med. Genet.

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To date, much progress has been made in the fields of cytogenetics and molecular genetics of renal tumors. The previous and recent findings have delineated the characteristics of the various tumors, particularly the cytogenetic and molecular differences that exist between papillary and nonpapillary clear cell renal cell carcinomas (RCCs). At the same time, new cytogenetic subtypes have emerged [e.g., t(X;1)] in subtypes of RCC, while in others (e.g., Wilms tumors) several new cytogenetic abnormalities and consequent molecular involvement have been found. In addition to Wilms tumor, papillary RCC, and clear-cell RCC, cytogenetic and fluorescence in situ hybridization analyses have been performed on several other tumors of the kidney, including chromophobic carcinoma, metanephric adenoma, collecting duct carcinoma, transitional cell carcinoma, congenital mesoblastic nephroma, and malignant rhabdoid tumors of the kidney. This review is therefore intended to present a concise update on the cytogenetic and molecular data on renal tumors, focusing mainly on the clinical usefulness of the findings reported in the literature.

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“…In addition, conventional cytogenetic and fluorescence in situ hybridization (FISH) studies have shown that ROs may demonstrate chromosomal rearrangement at 11q13, involving the CCND1 locus [10][11][12][13][14][15][16][17][18][19]. However, the frequency of cyclin D1 overexpression and CCND1 rearrangements as well as the association with unique histologic and clinical features has not been studied in RO or ChRCC.…”

Section: Introductionmentioning

confidence: 99%