Renal oncocytoma. Report of five cases and review of literature

Yu, Gloria S.M.; Rendler, Solomon; Herskowitz, Ahvie; Molnar, John J.

doi:10.1002/1097-0142(19800301)45:5<1010::aid-cncr2820450530>3.0.co;2-3

Cited by 81 publications

(5 citation statements)

References 17 publications

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“…This may indicate that the incidence of renal oncocytoma is increasing, a notion that was already advocated by Klein & Valensi (1976). In the present series the increase in recent years was striking, and similar results have been reported in several other studies (Yu et al 1980, Morales et al 1980, Merino & Livolsi 1982, Barnes & Beckman 1983. In the Mayo Clinic material of 90 patients no such increase could, however, be demonstrated (Lieber et al 1981).…”

Section: Discussionsupporting

confidence: 90%

Renal oncocytoma: the incidence of 18 surgical and 12 autopsy cases

et al. 1984

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The material of 562 surgically removed renal cell carcinomas or adenomas was reviewed, and 18 tumors were diagnosed as renal oncocytomas. The incidence seemed to increase strikingly during recent years. Similarly, among 112 renal cell tumours from 8489 autopsies, 12 oncocytomas were found. Immunoperoxidase staining for alpha-I-antichymotrypsin was positive in all the tumours studied speaking for the origin from proximal tubular cells. All the tumours behaved in a benign fashion despite the large size and/or moderate histological atypia. The recognition of renal oncocytoma is urged, because its incidence seems to be increasing, and the prognosis is much better than that of renal cell carcinoma.

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Section: Discussionsupporting

confidence: 90%

Renal oncocytoma: the incidence of 18 surgical and 12 autopsy cases

et al. 1984

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“…'~-'~ Loss of characteristic cytoarchitectural features is, however, common to oncocytes in general and may only represent a stage of transformation of the oncocyte from its cell of origin. 18 Our findings indicate that all renal cell carcinomas share Unlike renal cell carcinomas, oncocytomas which lack membrane specialization on electron microscopy do not react with brush border antibodies?6 However, they do stain for AATZ8 and ly~ozyme,~~ prox- imal tubule markers. They do not stain for Tamm-Horsfall protein of distal tubular origin, l 7 although oncocytes may be unable to synthesize this protein.…”

Section: Fig I A-1 D (A) Renal Proximal Tubules (Above Glomerulus) mentioning

confidence: 78%

Histogenesis of renal cell carcinoma and renal oncocytoma: An immunohistochemical study

Cohen

McCue

DeRose

1988

Cancer

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The histogenesis of renal cell carcinoma and oncocytoma is controversial. We compared immunohistochemical profiles of normal kidney, nine carcinomas, and six oncocytomas. Carcinomas and oncocytomas expressed the following antigens respectively: proximal tubule--Uro 3 (56 & 67%), alpha-1-antitrypsin (89 & 50%); proximal and distal tubule--Uro 10 (67 & 83%); distal tubule--B2-microglobulin (100 & 100%); distal/medullary tubule--epithelial membrane antigen (89 & 83%), neuron-specific enolase (78 & 100%), glandular cytokeratin (78 & 100%), epidermal keratin (67 & 67%); and medullary tubule--Uro 8 (89 & 83%). All tumors, except one oncocytoma, had at least one positive reaction for each antigen group. Oncocytomas predominantly stained for distal/medullary tubular antigens; none showed a predominance of proximal tubular antigens. Carcinomas also demonstrated largely distal/medullary tubule antigens; 44% showed prominence of proximal tubular antigens as well. Assignment of an exclusive proximal, distal or medullary tubule origin to renal neoplasms does not appear valid. Divergent histogenesis from a precursor stem cell is likely.

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“…Since Klein and Valensi [1 ] drew attention to renal oncocytoma in 1 976, clinicians have become increasingly aware of this neoplasm as a distinct pathologic entity [2]. Various descriptions of the angiographic [3][4][5][6][7] and computed tomographic (CT) [3,8,9] We sought specific characteristics that might help to distinguish oncocytoma from renal cell carcinoma.…”

Section: Contained Areas Of Central Necrosis or Calcificationmentioning

confidence: 99%