2001
DOI: 10.1152/ajprenal.2001.280.1.f10
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Renal Na+-glucose cotransporters

Abstract: In humans, the kidneys filter approximately 180 g of D-glucose from plasma each day, and this is normally reabsorbed in the proximal tubules. Although the mechanism of reabsorption is well understood, Na(+)-glucose cotransport across the brush-border membrane and facilitated diffusion across the basolateral membrane, questions remain about the identity of the genes responsible for cotransport across the brush border. Genetic studies suggest that two different genes regulate Na(+)-glucose cotransport, and there… Show more

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Cited by 584 publications
(568 citation statements)
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“…As we made comparable observations using D-galactose instead of D-glucose we were able to exclude other members of this SGLT family (SGLT-2 and SGLT-3), since SGLT-1 does not discriminate between D-glucose and D-galactose, while neither SGLT-2 nor SGLT-3 transport D-galactose efficiently (K m >20 mmol/l) [31].…”
Section: Additive Effects Of D-glucose and Insulin On Nitric Oxide Fomentioning
confidence: 79%
See 1 more Smart Citation
“…As we made comparable observations using D-galactose instead of D-glucose we were able to exclude other members of this SGLT family (SGLT-2 and SGLT-3), since SGLT-1 does not discriminate between D-glucose and D-galactose, while neither SGLT-2 nor SGLT-3 transport D-galactose efficiently (K m >20 mmol/l) [31].…”
Section: Additive Effects Of D-glucose and Insulin On Nitric Oxide Fomentioning
confidence: 79%
“…2d). The transporter isoforms SGLT-1 and GLUT1 have been shown to transport D-galactose as efficiently as D-glucose [30,31]. Accordingly, the effect of D-galactose on endothelial NO release (E max =4.1±0.4 nmol/l, 4.2±0.3 min, n=5) (Fig.…”
Section: Coupling Of High Glucose With Ncx-dependent Enos Activationmentioning
confidence: 99%
“…In addition to the GLUT isoforms that we studied, there are another seven known isoforms (GLUT-6 to 12) [9], at least two other isoforms of SGLT [55], and the proton-myoinositol symporter [9]. Antibodies to some of these transporters became available after this study was completed, and for this reason we have not examined their role in the vascular endothelial cell.…”
Section: Glut-2mentioning
confidence: 99%
“…the melibiose transporter (MelB) of E. coli mediates uphill transport of melibiose coupled to Na + or H + (Botfield et al, 1990), while that of Klebsiella pneumoniae couples sugar transport to H + and Li + (Hama et al, 1992). Similarly, mammalian SGLT1 and SGLT3 can utilize H + or Li + in addition to Na + as the driving force for sugar transport, whereas SGLT2 is Na + -specific (Wright, 2001).…”
mentioning
confidence: 99%