Renal mucinous and tubular spindle cell carcinoma: a clinicopathological study of 4 cases

Gaafar, Ayman; Valentí, Carla; Echevarría, Celina; Laforga, Juan B.; López, José I.

doi:10.5144/0256-4947.2006.466

Cited by 9 publications

(14 citation statements)

References 12 publications

(27 reference statements)

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“…MTSCCs are polymorphic neoplasms showing a wide range of morphologic variability [2]. Histologically, they are generally characterized by the presence of cuboidal and spindle cells [9].…”

Section: Discussionmentioning

confidence: 99%

“…Some cases might show predominance of various components: some MTSCCs may show spindle cell predominance and mimic sarcomatoid carcinomas, and others may show tubular cell predominance and mimic the solid variant of papillary RCC [2]. Other characteristic features include tumors with poor mucin content, areas with extracellular hyaline matrix and blue-tinged mucin within tubules, and solid areas with epithelioid cells [2]. MTSCCs are known to originate from the collecting duct epithelium or cells of the loop of Henle [8].…”

Section: Discussionmentioning

confidence: 99%

“…It is a relatively lowgrade carcinoma and is associated with a good prognosis [2]. The clinical characteristics of MTSCC are similar to those of papillary renal cell carcinoma (RCC) with sarcomatoid transformation.…”

Section: Introductionmentioning

confidence: 99%

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Mucinous tubular and spindle cell carcinoma of the kidney

et al. 2012

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Mucinous tubular and spindle cell carcinoma (MTSCC) is a low-grade renal epithelial neoplasm that has recently been recognized as a specific entity in the 2004 World Health Organization classification of renal cell carcinoma. A 69-year-old woman was referred to our hospital because of incidental left renal tumor. Abdominal computed tomography showed a hypovascular tumor in the left kidney. Left radical nephrectomy was performed. Hematoxylin and eosin staining revealed cuboidal and oval or spindle-shaped cells in tubular and papillary patterns embedded in the myxoid stroma. Immunohistochemically, the tumor cells were positive for alpha-methylacyl-CoA racemase. On the basis of these findings, we diagnosed the patient as having MTSCC.

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“…MTSCCs are polymorphic neoplasms showing a wide range of morphologic variability [2]. Histologically, they are generally characterized by the presence of cuboidal and spindle cells [9].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Mucinous tubular and spindle cell carcinoma of the kidney

et al. 2012

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“…Gaafar et al. reported that MTSCC‐K accounts for less than 0.8% of renal neoplasms 2 . In fact, even though this pathological entity was first recognized in 2001 by Parwani et al.…”

Section: Discussionmentioning

confidence: 99%

“…Mucinous tubular and spindle cell carcinoma of the kidney (MTSCC‐K) is a relatively rare pathological entity that has recently been described in the World Health Organization 2004 renal cell carcinoma (RCC) classification 1 . Previously, it was reported that this type of RCC showed relatively good prognosis 2 . A precise differential diagnosis between MTSCC‐K and papillary RCC with sarcomatoid transformation is important for predicting patient prognosis 3 .…”

Section: Introductionmentioning

confidence: 99%

A case of renal mucinous tubular and spindle cell carcinoma

et al. 2009

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Abstract:A 33-year-old man was hospitalized for treatment of a left renal tumor. The radiological findings were consistent with those of a left renal cell carcinoma (RCC). Subsequently, a radical nephrectomy was carried out. Macroscopic examination showed that a well-demarcated tumor measuring 2.9 ¥ 2.6 ¥ 2.5 cm was present in the middle portion of the resected kidney. The cut surface of the tumor was grayish-white in color. Pathological examination of the resected specimen showed a mucinous tubular and spindle cell carcinoma of the kidney (MTSCC-K). MTSCC-K is a low-grade renal epithelial neoplasm that has recently been recognized as a specific entity in the World Health Organization 2004 classification of RCC. To our knowledge, 17 cases of MTSCC-K in Japan have been reported by Japanese investigators. To avoid administration of excessive adjuvant treatment to patients, pathologists and urologists should consider this newly recognized low-grade malignancy when diagnosing renal tumors.

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