Renal morbidity in type 2 diabetes mellitus patients with and without non-alcoholic fatty liver disease

Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) is independently associated with with prevalent as well as incident cardiovascular diseases (CVD), type 2 diabetes mellitus (T2DM), chronic kidney disease (CKD) and Metabolic syndrome (MetS). Awareness of Renal Morbidity and full understanding is work at progress. Hence it was determined to assess the Renal morbidity as measured by eGFR in patients of T2DM with and without NAFLD. Methods: Patients with T2DM (ICMR 2018 criteria) with proper informed and valid consent and satisfying essential inclusion and exclusion criteria were screened for presence of fatty liver by ultrasound and were divided into two groups; those with NAFLD and without NAFLD. All patients were investigated for renal morbidity in terms of eGFR using MDRD formula. Result: Diabetic patients with NAFLD had lower eGFR levels compared to diabetics without NAFLD (p<0.05). Patients with diabetes and NAFLD has significantly higher BMI, WHR, duration of diabetes compared to Diabetes patients without NAFLD. Conclusions: Group of diabetics with NAFLD have to be closely monitoring for serum creatinine levels and BMI is required for early intervention and optimisation of treatment. Elderly patients required more prompt monitoring.