“…In the current issue of AIDS, Hunt et al [6] evaluated the presence of the mitochondrial DNA common deletion in urine samples from 97 west-African people with HIV (mean age 49 years, 74% women), including 38 on a TDF-containing regimen which they had been taking for a median of 81 months. The common deletion was present in 32% of those not exposed to thymidine analogues (nucleoside RTI with systemic mitochondrial toxicity; mainly zidovudine) and in 37% of those exposed to TDF (P ¼ 0.22), and no more prevalent among those on TDF with prior exposure to thymidine analogues.…”