Renal metabolism of corticosteroid hormones

Hierholzer, Klaus; Lichtenstein, I.; Siebe, H.; Tsiakiras, D.; Witt, I.

doi:10.1007/bf01715842

Cited by 13 publications

(3 citation statements)

References 30 publications

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“…the latter being an important enzyme which in the rat kidney converts B into 11-dehydro-B [19][20][21][22]. 11-Dehydro-B has only a limited mineralocor- ticoid and perhaps also glucocorticoid activity as compared to B [23][24][25][26].…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Localization of 11-Hydroxysteroid Dehydrogenase in Rat Kidney with a Monoclonal Antibody

Castello¹,

Schwarting²,

Muller³

et al. 1989

Kidney Blood Press Res

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Monoclonal antibody (MAb) against 11-hydroxysteroid dehydrogenase (11-HSD) has been raised by immunization of female balb/c mice. 11-HSD from solubilized rat renal microsomal protein could be bound in a modified ELISA using antimouse IgG and MAb against 11-HSD. On Western blots of solubilized rat renal microsomes the MAb recognized a single protein band of an approximate molecular weight of 35 kD. Immunohistochemical staining of rat renal tissue with the above MAb and the APAAP staining technique displayed a heterogenous reginal and subcellular distribution: glomeruli and arterioles were practically devoid of specific staining, as were epithelial cells in inner and outer medulla. Intense immunostaining was observed in PCT and particularly in PST, appearing granular with highest density around the nuclei. Here the enzyme bound to intracellular membranes may exert an autocrine function such as signal inactivation. In contrast to cortex, staining of interstitial cells was observed in renal medulla. The latter localization is compatible with the concept of a paracrine function of 11-HSD which might prevent corticosterone from gaining access to collecting duct cells.

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Section: Discussionmentioning

confidence: 99%

Immunohistochemical Localization of 11-Hydroxysteroid Dehydrogenase in Rat Kidney with a Monoclonal Antibody

Castello¹,

Schwarting²,

Muller³

et al. 1989

Kidney Blood Press Res

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“…[22] showed that the healthy kidney transforms cortisone to cortisol. [23]. Another disturbance of cortisol metabolism can be observed in the 20a/20P-reductase system: the ratio of a-cor/P-cor is significantly decreased in most of our patients.…”

Section: Discussionmentioning

confidence: 58%

“…A corresponding enzyme, a 20a-reductase in rat kidney tissue was described by Hierholzer et af. [23].…”

Section: Discussionmentioning

confidence: 99%

Neutral steroid metabolites in patients with uraemia and after renal transplantation: a quantitative and qualitative study in body fluids

Ludwig-Köhn

Henning

Sziedat

et al. 1985

Eur J Clin Investigation

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Steroid metabolites enriched from urine, haemofiltrate, and CAPD-dialysate (Continuous Ambulatory Peritoneal Dialysis) were identified by gas chromatography-mass spectrometry and quantified by capillary gas chromatography. The study included twenty healthy controls, twenty-six non-dialysed uraemics, thirty-nine patients on regular dialysis treatment, and twenty-two allograft recipients. Compared to the 24 h urinary excretion rates of controls the excretion rates of androsterone and etiocholanolone were in the lower normal range up to significantly decreased in the body fluids of all patients, and those of the corticoid metabolites were also significantly decreased. 11-Oxygenated androstanolones in urine from non-dialysed uraemics correlated significantly decreased. 11-oxygenated androstano-levels and were significantly increased, but normal in haemofiltrate and CAPD-dialysate, while in urine of allograft recipients the values were significantly lower.

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Biochemical Characterization of Individual Nephron Segments

Guder

Morel

1992

Comprehensive Physiology

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The sections in this article are: Biochemical Basis of Active Tubular Transport Biochemical Mechanisms of Hormone Action Cyclic AMP as Intracellular Messenger of Hormones Inositol Polyphosphates, Diacylglycerol, and Ca 2+ as Hormone Messengers Insulin and Growth Factors Action of Steroid Hormones Including Vitamin D Hormone Thyroid Hormones Biochemical Functions of the Proximal Tubule Coupling of Metabolism and Transport Brush‐Border Enzymes Renal Gluconeogenesis Amino Acid and Peptide Metabolism Biotransformation Reactions Thin Limbs of Henle's Loop Thick Ascending Limb of Henle's Loop Tamm‐Horsfall Glycoprotein The Distal Convoluted Tubule The Collecting Tubule Metabolism and Transport ATPases Organic Osmolytes

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Renal metabolism of corticosteroid hormones

Cited by 13 publications

References 30 publications

Immunohistochemical Localization of 11-Hydroxysteroid Dehydrogenase in Rat Kidney with a Monoclonal Antibody

Immunohistochemical Localization of 11-Hydroxysteroid Dehydrogenase in Rat Kidney with a Monoclonal Antibody

Neutral steroid metabolites in patients with uraemia and after renal transplantation: a quantitative and qualitative study in body fluids

Biochemical Characterization of Individual Nephron Segments

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