Renal Medullary Carcinoma

Steele, Erica L.; MacLennan, Gregory T.

doi:10.1097/01.ju.0000179131.27104.6f

Cited by 7 publications

(3 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PBS was used as a negative control for the primary antibody for each group. All renal tumors were confirmed to be RMC based upon the histological examination and immunohistochemical findings (1,13).…”

Section: Methodsmentioning

confidence: 99%

Clinical and computed tomography imaging features of renal medullary carcinoma: A report of six cases

et al. 2015

View full text Add to dashboard Cite

Abstract. Patients with renal medullary carcinoma (RMC) have a poor prognosis, usually due to late diagnosis. Computed tomography (CT) analysis may aid the differentiation between RMC and other types of renal cell carcinoma, in order to establish an accurate early diagnosis. There is a limited number of reports in the literature focusing on clinical and multi-slice CT (MSCT) imaging findings of RMC. Consequently, the present study aimed to characterize the clinical and MSCT imaging features of RMC. For this purpose, the MSCT imaging findings of 6 patients with RMC were retrospectively studied. The patients were subjected to MSCT in order to investigate the characteristics of the tumors, including location, size, density, calcification, cystic or solid appearance, capsule sign, enhancement pattern and presence of retroperitoneal lymph node metastasis. The tumors in the current study presented a mean diameter of 7.48±3.25 cm, and were observed to be solitary and heterogeneous with necrotic components. The majority of the tumors did not contain calcifications (5/6); displayed an ill-defined margin (4/6); were centered in the medulla; extended into the renal pelvis or peripelvic tissues (6/6); and did not exhibit a fibrous capsule. Localized caliectasis was observed in 3 of the 6 cases. The attenuation of the solid region of the RMC on unenhanced CT was equal to that of the renal cortex or medulla (42.3±2.7 vs. 40.7±3.6 and 41.2±3.9 Hounsfield units, respectively; P>0.05) while, on enhanced CT, the enhancement of the tumor was lower than that of the normal renal cortex and medulla during all phases (cortical phase, 52.6±4.8 vs. l99.5±9.7 and 72.7±6.4; medullary phase, 58.6±5.7 vs. 184.6±10.8 and 93.5±7.8; delayed phase, 56.8±6.1 vs. 175.7±8.5 and 96.5±7.9, respectively; P<0.05).In conclusion, RMC tends to be an infiltrative, ill-defined heterogeneous mass with intratumoral necrosis, which arises from the renal medulla, and displays lower enhancement than the renal cortex and medulla during all phases on enhanced CT. Despite its rarity in adults, RMC should be included in a differential diagnosis when CT imaging reveals these features.

show abstract

Section: Methodsmentioning

confidence: 99%

Clinical and computed tomography imaging features of renal medullary carcinoma: A report of six cases

et al. 2015

View full text Add to dashboard Cite

show abstract

“…39 In addition, RMC typically has a fair amount of inflammatory infiltrate and reactive stromal elements, unlike most types of RCC. 8 Other renal neoplasms that present with central location and infiltrative …”

Section: Histopathologymentioning

confidence: 99%

Renal Medullary Carcinoma in a White Adolescent With Sickle Cell Trait

Daher

Bourgi²,

Riachy³

et al. 2014

Journal of Pediatric Hematology/Oncology

View full text Add to dashboard Cite

Renal medullary carcinoma (RMC) is a rare neoplasm of the kidney that has been recently described. It is almost exclusive to young patients of African descent and associated with sickle cell hemoglobinopathy, mainly sickle cell trait and hemoglobin sickle cell disease. The prognosis of RMC is very poor because of the highly aggressive behavior of this neoplasm and its resistance to conventional chemotherapy. Metastatic disease is almost universal at the time of presentation, and the malignancy is minimally responsive to a variety of regimens and/or modalities, including surgery, radiotherapy, chemotherapy, and biological immune-modulation therapy. We report the seventh case of a left RMC occurring in a white child with sickle cell trait, but with a localization of the tumor in the left kidney, considered a nonpredominant side for this type of tumor.

show abstract

“…Most RMCs have hemorrhagic and necrotic areas (1). The cells have large and clear vesicular nuclei, prominent nucleoli, and dark cytoplasm with variable amounts of eosinophilic cytoplasm (9). There is frequently lymphatic and/or vascular invasion (1).…”

Section: Introductionmentioning

confidence: 99%

Imaging of Renal Medullary Carcinoma

Greco

Faiella

Santucci

et al. 2017

jkcvhl

View full text Add to dashboard Cite

Renal medullary carcinoma (RMC) is a rare, highly aggressive tumor recognized as an independent pathological entity. African-descent adolescents and young adults with sickle cell hemoglobinopathy are the most affected groups. This rare subtype of renal cell carcinoma has its own morphogenetic and pathological characteristics. The major clinical manifestations include gross hematuria, abdominal or flank pain, and weight loss. The prognosis is very poor, with 95% of cases diagnosed at an advanced stage of the disease. In this review, we summarize the morphologic and dynamic characteristics of RMC under various imaging modalities such as ultrasound, computed tomography, and magnetic resonance. Differential diagnosis and management strategies are also discussed.

show abstract

Renal Medullary Carcinoma

Cited by 7 publications

References 1 publication

Clinical and computed tomography imaging features of renal medullary carcinoma: A report of six cases

Clinical and computed tomography imaging features of renal medullary carcinoma: A report of six cases

Renal Medullary Carcinoma in a White Adolescent With Sickle Cell Trait

Imaging of Renal Medullary Carcinoma

Contact Info

Product

Resources

About