Renal masses measuring under 2cm: Pathologic outcomes and associations with MRI features

Rosenkrantz, Andrew B.; Wehrli, Natasha E.; Melamed, Jonathan; Taneja, Samir S.; Shaikh, Mohammed Bilal

doi:10.1016/j.ejrad.2014.05.016

Cited by 13 publications

(12 citation statements)

References 22 publications

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“…The remainder of the studies were single‐center analyses. Ten studies were completed in Asia, 9 were completed in North America, and 1 was completed in Europe . The median study start year was 2000 (1988‐2010).…”

Section: Resultsmentioning

confidence: 99%

“…Notably, 19 of the 20 studies incorporated a component of imaging, and 2 studies used imaging alone. Ten studies were designed to predict malignant pathology, whereas the remaining 10 were designed to predict benign pathology . The strength of evidence was considered low for preoperative composite models as a whole because of differences in patient populations and discordant variables included in the models.…”

Section: Resultsmentioning

confidence: 99%

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Distinguishing malignant and benign renal masses with composite models and nomograms: A systematic review and meta‐analysis of clinically localized renal masses suspicious for malignancy

Pierorazio

Patel

Johnson

et al. 2016

Cancer

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Solid renal masses and cystic lesions with solid components are suspicious for renal cell carcinoma. Without an effective screening test, composite models and nomograms rely on patient and tumor characteristics to stratify the risk of benign disease versus malignant disease. To guide decisions about the use of renal mass sampling or excision, a systematic review and meta-analysis of the ability of composite models to predict the likelihood of malignancy on the basis of preoperative clinical variables was performed. MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were searched from January 1, 1997, through May 1, 2015, according to the Preferred Reporting Items for Systematic Review and Meta-Analyses statement. Composite models necessarily included imaging results and at least 1 element from the following to be compared with surgical pathology: demographic characteristics, clinical characteristics, and blood or urine tests. Two independent reviewers screened citations and extracted data. Quality Assessment Tool for Diagnostic Accuracy Studies 2 was used to assess the risk of bias. The strength of evidence was graded with the scheme recommended by Methods Guide for Effectiveness and Comparative Effectiveness Reviews. Twenty studies (12,149 patients) were included in this review. The only significant predictors of malignancy in the composite models were tumor size (effect size, 1.33-fold increased risk per centimeter; 95% confidence interval [CI], 1.22-1.43) and male sex (effect size, 2.71; 95% CI, 2.39-3.02). The results were inconclusive or not significant for tumor characteristics, age, body mass index, and incidental presentation. In conclusion, composite models currently have a limited ability to distinguish malignant renal masses from benign renal masses, with increased tumor size and male sex associated with malignancy. Cancer 2016;122:3267-3276. © 2016 American Cancer Society.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Distinguishing malignant and benign renal masses with composite models and nomograms: A systematic review and meta‐analysis of clinically localized renal masses suspicious for malignancy

Pierorazio

Patel

Johnson

et al. 2016

Cancer

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“…A recent meta-analysis showed that significantly lower apparent diffusion coefficient (ADC) values were found in RCC compared with oncocytomas, although these data are still controversial [30]. In addition, magnetic resonance imaging presents high limitations in the discrimination of SRMs o2 cm [31].…”

Section: The Role Of Imaging In Patients With Srmsmentioning

confidence: 98%

Small renal masses in the era of personalized medicine: Tumor heterogeneity, growth kinetics, and risk of metastasis

Conti¹,

Santoni²,

Sotte³

et al. 2015

Urologic Oncology: Seminars and Original Investigations

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“…The benign mass types included oncocytoma (72.9 %), angiomyolipoma (17.8 %), and papillary adenoma (4.3 %). In another recent study, more than 25 % of lesions measuring less than 2 cm were benign [5]. High-grade malignancy was found in only 7.6 % lesions less than 2 cm and none in lesions measuring less than 1 cm [5].…”

Section: Introductionmentioning

confidence: 95%

“…In another recent study, more than 25 % of lesions measuring less than 2 cm were benign [5]. High-grade malignancy was found in only 7.6 % lesions less than 2 cm and none in lesions measuring less than 1 cm [5]. A recent meta-analysis suggests that approximately 40 % of tumors that measure less than 1 cm and about 20 % of those that measure between 1 and 4 cm are benign [6 •• ].…”

Section: Introductionmentioning

confidence: 98%

Renal Mass Biopsy in the Era of Surgical Alternatives

et al. 2015

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Until recently, most solid renal masses identified on imaging were presumed to be renal cell carcinomas and were treated with surgical resection. New and improved treatment modalities and advances on imaging and histological diagnostic techniques have led to a change in this paradigm. Imaging-guided biopsy is now an established step in the management of many patients with newly diagnosed renal masses. In this article, we describe a decision-making protocol to help selecting patients who should or should not undergo biopsy.

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Renal masses measuring under 2cm: Pathologic outcomes and associations with MRI features

Cited by 13 publications

References 22 publications

Distinguishing malignant and benign renal masses with composite models and nomograms: A systematic review and meta‐analysis of clinically localized renal masses suspicious for malignancy

Distinguishing malignant and benign renal masses with composite models and nomograms: A systematic review and meta‐analysis of clinically localized renal masses suspicious for malignancy

Small renal masses in the era of personalized medicine: Tumor heterogeneity, growth kinetics, and risk of metastasis

Renal Mass Biopsy in the Era of Surgical Alternatives

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