Renal manifestations of dengue viral infection

Eswarappa, Mahesh; Reddy, Sujeeth; John, Manns Manohar; Suryadevara, Sarita; Madhyashatha, Rakesh Parampalli

doi:10.4103/1319-2442.256847

Cited by 16 publications

(10 citation statements)

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“…In our study, among 316 dengue patients, thirty-one patients (9.8%) had renal involvement. Eswarappa et al's retrospective study showed prevalence of renal manifestation in dengue fever is 9.02% of the study population, which is similar to our study [10].…”

Section: Discussionsupporting

confidence: 91%

“…Retrospective studies of case series of dengue have shown that the development of AKI was associated with a longer hospital stay and higher mortality [10,18,22,[24][25][26] which is similar to our study.…”

Section: Discussionsupporting

confidence: 91%

“…e results showed that the incidence of AKI among patients with dengue upon admission to the hospital was 35.7% [19]. Eswarappa et al in another recent retrospective study found AKI in 82 patients (3.4%) using AKIN staging with AKIN stage I seen in 58 patients (70.73%) [10]. In the present study, we found 42% had AKI which is close to study of Basu et al where they found 35.7% [19].…”

Section: Discussionsupporting

confidence: 85%

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Renal Involvement in Children with Dengue Fever: A Study in Tertiary Care Hospital of Bangladesh

Sultana

Rumana²,

Roy

et al. 2020

International Journal of Nephrology

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Background and Objective: Dengue has emerged globally as the most relevant viral infection transmitted by a mosquito bite and represents a major threat to public health. Dengue-related renal manifestations such as proteinuria, hematuria, acute kidney injury (AKI), and rhabdomyolysis are not uncommon, and acute kidney injury (AKI) is a serious complication of dengue fever. There is relatively few data on the renal manifestations of dengue fever in children. Hence, this study was conducted to evaluate the incidence, characteristics, and clinical outcome of dengue fever with renal manifestations. Method. This prospective cross sectional study was conducted in Dr. M R Khan Children Hospital and Institute of Child Health, Dhaka, over a period of 1 year from January 2018 to December 2018. The study was approved by the ethical committee of the institute. A total number of 316 patients were admitted with the diagnosis of dengue fever either NS1 positive or antibody IgM positive or both IgM and IgG positive. Data were collected in a structured questionnaire form and were analyzed by SPSS version 20.0. The disease severity was classified according to the World Health Organization criteria. Renal manifestations were divided into AKI groups using pRIFLE criteria. Proteinuria was defined as urinary protein >1+ (30 mg/dL) by dipstick test. Hematuria was defined as red blood cell (RBC) >5/μL in a fresh uncentrifuged urine specimen. Result. Among 316 dengue patients, thirty-one patients (9.8%) had renal involvement. Most of the patients (54.83%) with renal manifestations were aged between 1 and 5 years. A total of 14 patients were found to have proteinuria (4.4%). Nephrotic-range proteinuria was seen in only one patient (0.3%). AKI was defined by pRIFLE criteria and was seen in 13 patients (4.1%); among AKI 6 (46.15%) had risk, three patients (23.07%) had injury and 4 (30.7%) had failure and needed peritoneal dialysis. Death occurred in 3 patients (9.6%) in dengue with AKI who had failure. The incidence of renal manifestations (proteinuria, hematuria, and AKI) is as high as 9.8% among patients with dengue, and those with AKI had significant morbidity and mortality. Conclusion. Renal involvement in children with dengue is not uncommon. Dengue associated with AKI had significant mortality and morbidity.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 85%

See 1 more Smart Citation

Renal Involvement in Children with Dengue Fever: A Study in Tertiary Care Hospital of Bangladesh

Sultana

Rumana²,

Roy

et al. 2020

International Journal of Nephrology

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“…Acute kidney injury (AKI) and acute renal failure (ARF) are significant complications of dengue, and patients presenting SD are more likely to develop them [25,34,[36][37][38][39][40]. Rates of mortality due to AKI are 1% for classic dengue, 12-40% for DHF and 60% for DSS [41].…”

Section: Introductionmentioning

confidence: 99%

Brazilian Dengue Virus Type 2-Associated Renal Involvement in a Murine Model: Outcomes after Infection by Two Lineages of the Asian/American Genotype

et al. 2021

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Dengue virus type 2 (DENV-2) is, traditionally, the most studied serotype due to its association with explosive outbreaks and severe cases. In Brazil, almost 20 years after the first introduction in the 1990s, a new lineage (Lineage II) of the DENV-2 Asian/American genotype emerged and caused an epidemic with severe cases and hospitalizations. Severe dengue includes multiple organ failure, and renal involvement can be potentially related to increased mortality. In order to better understand the role of DENV infection in renal injury, here we aimed to investigate the outcomes of infection with two distinct lineages of DENV-2 Asian/American genotype in the kidney of a murine model. BALB/c mice were infected with Lineages I and II and tissues were submitted to histopathology, immunohistochemistry, histomorphometry and ultrastructural analysis. Blood urea nitrogen (BUN) was detected in blood sample accessed by cardiac puncture. A tendency in kidney weight increase was observed in mice infected with both lineages, but urea levels, on average, were increased only in mice infected with Lineage II. The DENV antigen was detected in the tissue of mice infected with Lineage II and morphological changes were similar to those observed in human dengue cases. Furthermore, the parameters such as organ weight, urea levels and morphometric analysis, showed significant differences between the two lineages in the infected BALB/c, which was demonstrated to be a suitable experimental model for dengue pathophysiology studies in kidneys.

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“…Nephrotic-range proteinuria was seen in 5 patients (2.16%). 8 The analysis of urine protein creatinine ratio (UPCR) at admission in 52 children with DVI, proteinuria was detected in 23.1% (n = 12) of the cases. Notably none of the children without DVI warning signs had proteinuria compared with 16.1% (5/31) with warning signs and 50% (7/14) in patients with severe dengue.…”

Section: Proteinuriamentioning

confidence: 99%

Renal Injury in Dengue Viral Infections

Ekambaram¹,

Geminiganesan²,

Nammalwar³

2020

Pediatric Infectious Disease

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Dengue virus infection (DVI), a tropical disease, caused by the bite of female Aedes aegypti and Aedes albopictus mosquitoes. The four distinct virus serotypes of the Flaviviridae family, DENV-1, DENV-2, DENV-3 and DENV-4, cause DVI. Dengue virus infection presents in different ways, ranging from a relatively innocuous flu-like dengue fever to severe dengue. Severe dengue fever is often associated with renal injury ranging from a mild and transient elevation of serum creatinine (SCr), proteinuria, erythrocyturia, dyselectrolytemia, glomerulonephritis, nephrotic syndrome to acute kidney injury (AKI). Acute kidney injury, an infrequent complication of dengue, is usually associated with hypotension, rhabdomyolysis, or hemolysis. Sadly, the existence of renal injury in DVI and its role in the outcome is rarely recognized in clinical practice. This review is to remind ourselves to this overlooked entity of renal manifestations of dengue infection in the tropics.

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Renal manifestations of dengue viral infection

Cited by 16 publications

References 0 publications

Renal Involvement in Children with Dengue Fever: A Study in Tertiary Care Hospital of Bangladesh

Renal Involvement in Children with Dengue Fever: A Study in Tertiary Care Hospital of Bangladesh

Brazilian Dengue Virus Type 2-Associated Renal Involvement in a Murine Model: Outcomes after Infection by Two Lineages of the Asian/American Genotype

Renal Injury in Dengue Viral Infections

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