Renal lesions: controlled comparison between CT and 1.5-T MR imaging with nonenhanced and gadolinium-enhanced fat-suppressed spin-echo and breath-hold FLASH techniques.

Semelka, Richard C.; Shoenut, J P; Kroeker, M A; MacMahon, Ross; Greenberg, Howard M.

doi:10.1148/radiology.182.2.1732961

Cited by 102 publications

(42 citation statements)

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“…The loss of CMD has been previously reported in renal insufficiency, irrespective of its causes, both in AKI and CKD settings. These findings were obtained using various MRI techniques - mostly T 1 W and CE-MRI [31,32,33,34,35,36,37]. Though nonspecific to CKD or AKI, this loss of CMD was found to be in parallel with the fall in the glomerular filtration rate [31].…”

Section: Discussionmentioning

confidence: 99%

Assessment with Unenhanced MRI Techniques of Renal Morphology and Hemodynamic Changes during Acute Kidney Injury and Chronic Kidney Disease in Mice

Milman

Axelrod²,

Heyman³

et al. 2014

Am J Nephrol

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Background/Aims: Changes in renal oxygenation and perfusion have been identified as common pathways to the development and progression of renal disease. Recently, the sensitivity of hemodynamic response imaging (HRI) was demonstrated; this is a functional magnetic resonance imaging (MRI) method combined with transient hypercapnia and hyperoxia for the evaluation of renal perfusion and vascular reactivity. The aim of this study was to utilize HRI for the noninvasive evaluation of changes in renal hemodynamics and morphology during acute, chronic and acute-on-chronic renal failures. Methods: Renal-HRI maps and true fast imaging with steady-state precession (True-FISP) images were used to evaluate renal perfusion, morphology and corticomedullary differentiation (CMD). MR images were acquired on two mouse models of kidney injury: adenine-induced chronic kidney disease (CKD) and rhabdomyolysis-induced acute kidney injury (AKI). Serum urea was measured from these mice in order to determine renal function. Results: Renal-HRI maps revealed a blunted response to hypercapnia and hyperoxia with evolving kidney dysfunction in both models, reflecting hampered renal vascular reactivity and perfusion. True-FISP images showed a high sensitivity to renal morphological changes, with different patterns characterizing each model. Calculated data obtained from HRI and True-FISP during the evolution of renal failure and upon recovery, with and without protective intervention, closely correlated with the degree of renal impairment. Conclusions: This study suggests the potential combined usage of two noninvasive MRI methods, HRI and True-FISP, for the assessment of renal dysfunction without the potential risk associated with contrast-agents administration. HRI may also serve as a research tool in experimental settings, revealing the hemodynamic changes associated with kidney dysfunction.

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Section: Discussionmentioning

confidence: 99%

Assessment with Unenhanced MRI Techniques of Renal Morphology and Hemodynamic Changes during Acute Kidney Injury and Chronic Kidney Disease in Mice

Milman

Axelrod²,

Heyman³

et al. 2014

Am J Nephrol

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“…Patients with the level of tumor thrombus located inferior to the diaphragm only require laparotomy, while the detection of supradiaphragmatic extension will require a thoracoabdominal surgical approach. Although MRI has been proved superior to other modalities in tumor thrombus detecting and predicting the tumor thrombus level (18,19), it is not easily available and not proper for patients with pacemaker or altered cardio-pulmonary function. In a prospective study, Hallscheidt found no difference in tumor thrombus staging of 23 patients who underwent MRI plus MDCT preoperatively (20).…”

Section: Discussionmentioning

confidence: 99%

The accuracy of multidetector Computed Tomography for preoperative staging of renal cell carcinoma

et al. 2012

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ARTICLE INFO _________________________________________________________ ___________________Purpose: The purpose of this study was to evaluate the accuracy of multidetector computed tomography (MDCT) in the preoperative staging of renal cell carcinoma (RCC). Materials and Methods:We retrospectively reviewed the clinical and pathological records of 312 patients with RCC who underwent staging MDCT before surgery. Radiographic findings were compared to the findings at surgery and pathological examination. All staging used 2009 updated TNM classification. Results: The difference in tumor size between radiographic and pathological findings was 0.21cm. In T1a group, the difference was 0.33cm. Agreement between MDCT and histopathological findings was moderate for T staging (Kappa = 0.469), fair for N staging (Kappa = 0.322), and excellent for M staging (Kappa = 0.932). The sensitivity and specificity of MDCT in detecting perinephric fat invasion were 32.26% and 85.87%, in detecting tumor thrombosis were 84% and 100%, in detecting adrenal gland invasion were 60% and 95.79%, in detecting lymph node involvement were 50% and 96.36%, in detecting distant metastasis were 100% and 99.67%, respectively. In regard to stage grouping, 237 of 314 patients were correctly staged by MDCT, with an overall accuracy of 75.48%. Conclusions: MDCT with a dynamic contrast protocol is able to delineate RCC with high accuracy. However, a great portion of tumors were overstaged by MDCT because of overestimation of tumor size and poor visualization of infiltration of the perinephric fat. In addition, nodal metastatic lesion evaluation relies on node size only and remains a difficult task.

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“…The differing contrast relationship between tumor and urine may increase the ability to demonstrate and stage TCCA. Interestingly, although TCCA is a hypovascular tumor, those neoplasms all showed moderate enhancement following gadolinium administration, which presumably reflects the high sensitivity of MRI for the presence of gadolinium [13][14][15][16].…”

Section: Discussionmentioning

confidence: 99%

Transitional cell carcinoma of the upper urinary tract: staging by MRI

Weeks

Brown

et al. 1995

Abdom Imaging

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Renal lesions: controlled comparison between CT and 1.5-T MR imaging with nonenhanced and gadolinium-enhanced fat-suppressed spin-echo and breath-hold FLASH techniques.

Cited by 102 publications

References 0 publications

Assessment with Unenhanced MRI Techniques of Renal Morphology and Hemodynamic Changes during Acute Kidney Injury and Chronic Kidney Disease in Mice

Assessment with Unenhanced MRI Techniques of Renal Morphology and Hemodynamic Changes during Acute Kidney Injury and Chronic Kidney Disease in Mice

The accuracy of multidetector Computed Tomography for preoperative staging of renal cell carcinoma

Transitional cell carcinoma of the upper urinary tract: staging by MRI

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