Renal Lesions: Characterization with Diffusion-weighted Imaging versus Contrast-enhanced MR Imaging

Taouli, Bachir; Thakur, Ravi; Mannelli, Lorenzo; Babb, James S.; Kim, Sooah; Hecht, Elizabeth M.; Lee, Vivian S.; Israel, Gary M.

doi:10.1148/radiol.2512080880

Cited by 292 publications

(203 citation statements)

References 44 publications

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“…The ADC of AML with 1.5T MRI was reported to be within the range of 0.74 -1.58 © 10 -3 mm 2 /s. [18][19][20]27 The ADC of AML with 3T MRI was not previously reported, but it was 0.674 © 10 -3 mm 2 /s in our study. The ADC of UC with 1.5T MRI was reported to be within the range of 1.59-2.70 © 10 -3 mm 2 /s.…”

Section: Discussioncontrasting

confidence: 54%

“…Thus, both muscle component and fat component will cause the decrease of ADC value as previously reported. 27 Our findings indicated that DWI might contribute to a differentiation of clear cell RCC from hyperattenuating type fat poor AML. The differentiation between hyperattenuating type fat poor AML and papillary RCCs will be more difficult on the conventional findings of CT and MRI, because both show a prolonged enhancement and low T 2 intensity.…”

Section: Discussionmentioning

confidence: 59%

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Utility of Apparent Diffusion Coefficients in the Evaluation of Solid Renal Tumors at 3T

Sasamori

Saiki

Suyama

et al. 2014

MRMS

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Purpose: We assessed the usefulness of apparent diffusion coefficients (ADCs) for solid renal tumor imaging using diffusion-weighted magnetic resonance imaging (DWI) at 3T.Methods: This retrospective study assessed ADCs of 31 patients with renal tumors that were imaged using preoperative DWI. DWI was performed with the b values of 50, 500, and 1000 s/mm 2 , using a 3T magnetic resonance imaging (MRI) system (MAGNETOM Trio, 3T, Siemens Healthcare, Erlangen, Germany). The ADC map was calculated using the b values of 50 and 1000 s/mm 2 . ADCs of the different tumors were compared according to the Tukey-Kramer test.Results: The tumors were diagnosed as clear cell renal cell carcinoma (RCC; n = 20), papillary RCC (n = 1), infiltrating urothelial carcinoma (UC) of the kidney (n = 4), cystic RCC (n = 1), poorly differentiated carcinoma (n = 1), and angiomyolipoma (AML; n = 4). The mean ADC of clear cell RCC was significantly higher than that of infiltrating UC of the kidney (1.423 vs. 0.931 © 10 ¹3 mm 2 /s; P < 0.05), and the mean ADC of AML was significantly lower than that of clear cell RCC (0.674 vs. 1.423 © 10 ¹3 mm 2 /s; P < 0.01). Conclusion: ADCs used in DWI at 3T may be useful for differentiation of different types of solid renal tumors.

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Section: Discussioncontrasting

confidence: 54%

Section: Discussionmentioning

confidence: 59%

Utility of Apparent Diffusion Coefficients in the Evaluation of Solid Renal Tumors at 3T

Sasamori

Saiki

Suyama

et al. 2014

MRMS

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“…A potential alternative to increased use of biopsy might lie in the use of diagnostic imaging to characterize renal cortical tumors on the basis of their tissue composition, morphologic features, and/or contrast enhancement patterns (21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32). Doppler ultrasonography, contrast material-enhanced computed tomography, and magnetic resonance (MR) imaging have shown potential for enabling differentiation of clear cell renal carcinomas (which show increased vascular flow and enhance avidly) from papillary and chromophobe carcinomas (which show reduced vascular flow and less enhancement) (21)(22)(23)(24)(26)(27)(28)).…”

Section: Discussionmentioning

confidence: 99%

“…The potential value of diffusionweighted (DW) MR imaging for characterizing renal lesions has also been investigated (29)(30)(31)(32). A study by Wang et al (31) showed that clear cell carcinomas had significantly higher apparent diffusion coefficients than did papillary or chromophobe carcinomas.…”

Section: Genitourinary Imaging: Renal Cortical Tumorsmentioning

confidence: 99%

“…A study by Wang et al (31) showed that clear cell carcinomas had significantly higher apparent diffusion coefficients than did papillary or chromophobe carcinomas. Taouli et al (30) reported that in the differentiation of benign and malignant renal lesions, DW MR imaging (area under the receiver operating characteristic curve, 0.85) was less accurate than qualitative assessment of dynamic contrastenhanced MR imaging (area under the receiver operating characteristic curve, 0.94). Their analysis included benign hemorrhagic cysts and cystic renal cell carcinomas, and all benign and all malignant tumors were grouped and compared, without distinguishing histologic subtypes.…”

Section: Genitourinary Imaging: Renal Cortical Tumorsmentioning

confidence: 99%

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Renal Cortical Tumors: Use of Multiphasic Contrast-enhanced MR Imaging to Differentiate Benign and Malignant Histologic Subtypes

Vargas

Chaim²,

Lefkowitz³

et al. 2012

Radiology

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Purpose:To investigate the use of quantitative multiphasic contrast material-enhanced magnetic resonance (MR) imaging in differentiating between common benign and malignant histologic subtypes of renal cortical tumors. Materials and Methods:The institutional review board waived informed consent and approved this retrospective HIPAA-compliant study of 138 patients who underwent preoperative contrastenhanced MR imaging during the period of January 2004-December 2008. At surgery, 152 renal tumors were identified (77 clear cell, 22 papillary, 18 chromophobe, and 10 unclassified carcinomas; 16 oncocytomas; nine angiomyolipomas). Three readers independently identified and measured the most-enhanced area in each tumor and placed corresponding regions of interest in similar positions on images from the precontrast, corticomedullary, nephrographic, and excretory phases. The percentage change in signal intensity (%SI change) between precontrast imaging and each postcontrast phase was calculated.Interreader agreement was evaluated by using the overall concordance correlation coefficient (OCC). A linear mixed-effects model was used to estimate and compare the trajectories of the means of log %SI change across all phases between the six histologic subtypes. results:Interreader agreement was substantial to almost perfect (OCC, 0.77-0.88). The %SI change differed significantly between clear cell carcinomas and papillary and chromophobe carcinomas in all phases of enhancement (P , .0001-.0120). In addition, %SI change was significantly higher in angiomyolipomas than in clear cell carcinomas, but only in the corticomedullary phase (P = .0231). Enhancement did not differ significantly between clear cell carcinoma and oncocytoma in any phase (P = .2081-.6000). conclusion:Quantitative multiphase contrast-enhanced MR imaging offers a widely available, reproducible method to characterize several histologic subtypes of renal cortical tumors, although it does not aid differentiation between clear cell carcinomas and oncocytomas.q RSNA, 20121 From the Departments of Radiology (H

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Interventional Imaging and Radiation Safety

Arnold

Anderson

Baldwin

2013

Percutaneous Renal Surgery

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Renal Lesions: Characterization with Diffusion-weighted Imaging versus Contrast-enhanced MR Imaging

Abstract: DW imaging can be used to characterize renal lesions; however, compared with CE MR imaging, it is less accurate. DW imaging can be used to differentiate solid RCCs from oncocytomas and characterize the histologic subtypes of RCC.

Cited by 292 publications

References 44 publications

Utility of Apparent Diffusion Coefficients in the Evaluation of Solid Renal Tumors at 3T

Utility of Apparent Diffusion Coefficients in the Evaluation of Solid Renal Tumors at 3T

Renal Cortical Tumors: Use of Multiphasic Contrast-enhanced MR Imaging to Differentiate Benign and Malignant Histologic Subtypes

Interventional Imaging and Radiation Safety

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