Renal leiomyosarcoma in a cat

Evans, Dawn; Fowlkes, Natalie W.

doi:10.1177/1040638716638126

Cited by 14 publications

(15 citation statements)

References 31 publications

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“…3,4,12 In a study that included 1129 feline cases of intestinal neoplasia, only 14 were diagnosed with leiomyosarcoma (1.2%), with equal frequency in the colon and the small intestine. 3 There are reports of feline non-intestinal leiomyosarcomas, such as those involving the urinary bladder, 13 kidney, 14 female reproductive tract 15 and liver. 16 There are no reported cases of feline gastric leiomyosarcoma.…”

Section: Discussionmentioning

confidence: 99%

A case of gastric leiomyosarcoma in a domestic shorthair cat

Hart

Brownlie²,

Ogden

et al. 2018

Journal of Feline Medicine and Surgery Open Reports

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Case summaryA 10-year-old male neutered domestic shorthair cat presented with nausea and 1.2 kg weight loss over a 6 month period. Physical examination was unremarkable, and haematological and biochemical results were considered clinically unremarkable. Abdominal ultrasound revealed an 18 mm diameter heterogeneous mass in the stomach at the pyloric sphincter, protruding into the gastric lumen with loss of gastric wall layering. The remainder of the intestinal tract and abdominal viscera were unremarkable and no free fluid was detected. The mass was surgically resected via celiotomy and the adjacent lymph node excised for histopathology. Histopathology of the mass demonstrated neoplastic spindle cell proliferation, which was considered most likely to be of smooth muscle origin, and so a preliminary diagnosis of gastric leiomyosarcoma was given. Complete excision was confirmed. Immunohistochemistry excluded a gastrointestinal stromal cell tumour as a differential and strongly supported the diagnosis of gastric leiomyosarcoma. The cat recovered well postoperatively with supportive treatment. Repeat abdominal ultrasonography 3 and 6 months postoperatively showed no evidence of mass regrowth. Survival time at the time of reporting is 10 months.Relevance and novel informationTo our knowledge, this is the first report of gastric leiomyosarcoma in a cat. Based on this case, gastric leiomyosarcoma should be a differential diagnosis for cats presenting with a gastric mass.

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Section: Discussionmentioning

confidence: 99%

A case of gastric leiomyosarcoma in a domestic shorthair cat

Hart

Brownlie²,

Ogden

et al. 2018

Journal of Feline Medicine and Surgery Open Reports

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“…The most common primary renal tumour is lymphosarcoma, which in most cases is bilateral, followed by renal carcinomas that are usually unilateral (Gabor, Malik & Canfield 1998 ; Henry et al 1999 ). Additional primary renal tumours that have been demonstrated in cats include transitional cell carcinoma (Hanzlicek et al 2012 ), cystadenoma (Mosenco et al 2008 ), squamous cell carcinoma (Gomez Selgas, Scase & Foale 2014 ), adenoma (Clark & Wilson 1988 ), leiomyosarcoma (Evans & Fowlkes 2016 ); adenocarcinoma (Britt, Ryan & Howard 1985 ) and nephroblastoma (Henry et al 1999 ), with none reported to be paragangliomas. Bilateral renal carcinomas were demonstrated in a case report in one cat (Steinberg & Thomson 1994 ).…”

Section: Discussionmentioning

confidence: 99%

The diagnosis of bilateral primary renal paragangliomas in a cat

Friedlein¹,

Carter²,

Last³

et al. 2017

Journal of the South African Veterinary Association

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A 9-year-old sterilised female domestic short-hair cat was referred with a history of vomiting and anorexia of 3 months’ duration. Biochemistry, full-blood counts, thoracic radiographs, feline pancreatic-specific lipase, abdominal ultrasonography and feline immunodeficiency virus/feline leukaemia virus (FIV/FeLV) SNAP tests had been performed. Mild hypochloraemia and moderate hypokalaemia were evident on initial presentation. Abdominal ultrasonography initially revealed unilateral renal nodules on the left side. These were subjected to fine-needle aspiration and cytological evaluation. A neuroendocrine tumour was suspected, and biopsies via midline coeliotomy were taken to confirm the diagnosis. Initial histopathology diagnosed primary renal carcinomas or neuroendocrine neoplasia; however, the definitive diagnosis became renal paragangliomas after immunohistochemistry and transmission electron microscopy were performed. The cat was regularly monitored with serum biochemistry parameters, blood pressure determinations, thoracic radiographs and subsequent abdominal ultrasonography. Biochemistry, radiography and blood pressures remained normal over a 24-week follow-up period, while subsequent ultrasonography revealed tumour progression in both number and size in both kidneys. Primary neuroendocrine tumours of the kidney are frequently incorrectly diagnosed as other renal tumours such as renal cell carcinoma, mesonephric tumours or undifferentiated carcinomas. This case report highlights the importance of additional testing, including immunohistochemistry and transmission electron microscopy, to obtain a definitive diagnosis of paragangliomas.

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“…Aufgrund der histopathologischen Charakteristika und des immunhistochemischen Expressionsmusters handelte es sich in allen vier Fällen vermutlich um Leiomyosarkome. Sie wiesen histomorphologisch weitgehende Ähnlichkeiten mit den in der Literatur bei Hund und Katze beschriebenen Einzelfällen derartiger Neoplasien auf (13,28,37,38). Beim Menschen sind primäre renale pleomorphe Sarkome selten, wobei es sich in 50-60 % der Fälle um Leiomyosarkome handelt (33,42…”

Section: Histopathologische Und Immunhistochemische Untersuchungsbefundeunclassified