Renal late adverse effects after potentially nephrotoxic treatment for childhood cancer

Knijnenburg, Sebastiaan L.; Mulder, Renée L.; Meeteren, Antoinette Yn Schouten-van; Groothoff, Jaap W.; Bökenkamp, Arend; Kremer, Leontien; Jaspers, Monique W. M.

doi:10.1002/14651858.cd008944

Cited by 12 publications

(20 citation statements)

References 18 publications

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“…Age was not determined to be a risk factor of AKI in previous pediatric studies [3,[15][16][17][18], except by Rajpal et al [25], who reported older age (11 to 21 years versus 0 to 10 years) as a predictor of AKI requiring dialysis. Older age at treatment was reported to be an important risk factor of renal adverse events in multivariate analyses of pediatric patients with cancer who received chemotherapy [26]. We also found that older ages were independently predictive of all stages of AKI and severe AKI requiring RRT, suggesting that older children are more vulnerable to renal injury during allogeneic HCT.…”

Section: Discussionsupporting

confidence: 60%

“…Many post-transplant events such as lung toxicity, sepsis, cardiac involvement, admission to an intensive care unit, SOS, and acute GVHD are previously described risk factors for renal events in various pediatric and adult studies [1,2,24]. Among them, SOS is a repeatedly described risk factor [16,17,26,[30][31][32]. We found that hepatic SOS is an independent predictor of all stages of AKI and severe AKI requiring RRT.…”

Section: Discussionsupporting

confidence: 49%

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Acute Kidney Injury in Pediatric Patients Receiving Allogeneic Hematopoietic Cell Transplantation: Incidence, Risk Factors, and Outcomes

Koh

Sunkara

Kang

et al. 2018

Biology of Blood and Marrow Transplantation

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Acute kidney injury (AKI) is a common adverse event after hematopoietic cell transplantation (HCT). AKI is associated with early death or chronic kidney disease among transplant survivors. However, large-scale pediatric studies based on standardized criteria are lacking. We performed a retrospective analysis of 1057 pediatric patients who received allogeneic HCT to evaluate the incidence and risk factors of AKI according to AKI Network criteria within the first 100 days of HCT. We also determined the effect of AKI on patient survival. The 100-day cumulative incidences of all stages of AKI, stage 3 AKI, and AKI requiring renal replacement therapy (RRT) were 68.2% ± 1.4%, 25.0% ± 1.3%, and 7.6% ± .8%, respectively. Overall survival at 1 year was not different between patients without AKI and those with stage 1 or 2 AKI (66.1% versus 73.4% versus 63.9%, respectively) but was significantly different between patients without AKI and patients with stage 3 AKI with or without RRT requirement (66.1% versus 47.3% versus 7.5%, respectively; P < .001). Age, year of transplantation, donor type, sinusoidal obstruction syndrome (SOS), and acute graft-versus-host disease (GVHD) were independent risk factors for stages 1 through 3 AKI. Age, donor, conditioning regimen, number of HCTs, SOS, and acute GVHD were independent risk factors for AKI requiring RRT. Our study revealed that AKI was a prevalent adverse event, and severe stage 3 AKI, which was associated with reduced survival, was common after pediatric allogeneic HCT. All patients receiving allogeneic HCT, especially those with multiple risk factors, require careful renal monitoring according to standardized criteria to minimize nephrotoxic insults.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionsupporting

confidence: 49%

Acute Kidney Injury in Pediatric Patients Receiving Allogeneic Hematopoietic Cell Transplantation: Incidence, Risk Factors, and Outcomes

Koh

Sunkara

Kang

et al. 2018

Biology of Blood and Marrow Transplantation

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“…46 Hypertension imparts a significant disease burden in CCS, as almost one-fifth treated with nephrotoxic therapies develop (secondary) hypertension. 47 In this study, hypertension rates were significantly higher than population rates; for participants younger than 18 years of age, 11.3% had hypertension versus childhood population rates of 3.6%…”

Section: Discussionmentioning

confidence: 49%

Metabolic Health in Childhood Cancer Survivors: A Longitudinal Study in a Long-Term Follow-Up Clinic

Gunn

Emilsson

Gabriel

et al. 2016

Journal of Adolescent and Young Adult Oncology

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“…[4][5][6][7][8] A recent Cochrane systematic review on nephrotoxic childhood cancer treatments reported a prevalence of long-term renal impairment ranging from 0 to 84%. 9 This gap may be due to multiple factors. Data is not homogenous respect to the malignancies, treatments, outcomes measurements and time of follow-up.…”

Section: Introductionmentioning

confidence: 99%

Long-term renal function and hypertension in adult survivors of childhood sarcoma: Single center experience

Schiavetti

Pedetti

Varrasso

et al. 2018

Pediatric Hematology and Oncology

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Renal late adverse effects after potentially nephrotoxic treatment for childhood cancer

Cited by 12 publications

References 18 publications

Acute Kidney Injury in Pediatric Patients Receiving Allogeneic Hematopoietic Cell Transplantation: Incidence, Risk Factors, and Outcomes

Acute Kidney Injury in Pediatric Patients Receiving Allogeneic Hematopoietic Cell Transplantation: Incidence, Risk Factors, and Outcomes

Metabolic Health in Childhood Cancer Survivors: A Longitudinal Study in a Long-Term Follow-Up Clinic

Long-term renal function and hypertension in adult survivors of childhood sarcoma: Single center experience

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