Renal Involvement In Primary Sjögren’s Syndrome: Data From The Spanish Sjögrenser Cohort.

Abstract

Objectives To investigate the prevalence, associated factors, and effects of primary renal disease on morbidity in patients with primary Sjögren’s syndrome (pSS).Methods All patients in the SJÖGRENSER (registry of adult SSp patients of the Spanish Society of Rheumatology) cohort were retrospectively investigated for the presence of clinically significant renal involvement directly related to pSS activity.Results Of the 437 patients investigated, 39 (9%) presented overt renal involvement during follow-up. Severe renal disease necessitating kidney biopsy was relatively rare (23%). Renal involvement may complicate pSS at any time during the disease course and is associated with severe disease (indicated by higher scores of involvement, activity, and damage), systemic multiorgan involvement, and a higher frequency of lymphoma. Multivariate analysis showed that older age (odds ratio [OR] 1.03, 95% confidence interval [CI] 1.00–1.07), higher European League Against Rheumatism Sjogren’s Syndrome Disease Activity Index scores (OR 1.1, CI 1.03–1.18), serum anti-La/SSB positivity (OR 6.65, CI 1.41–31.372), and non-vasculitic cutaneous involvement (OR 5.47, 1.03–29.02) were independently associated with this complication. Chronic renal failure developed in 23 of 39 patients (59%); only 1 of them progressed to end-stage renal disease necessitating renal replacement therapy. Patients with renal disease showed higher Sjögren’s syndrome disease damage index scores, higher rates of hospitalization due to disease activity and higher rates of clinically relevant comorbidities.Conclusion Renal involvement is an uncommon complication in pSS that was observed in 9% of patients. Although categorized as a non-negligible comorbidity, this condition shows a favorable prognosis.

Indications and risk factors for hospitalization in patients with primary Sjögren syndrome: experience from a tertiary center in Turkey

“…The study proposed the idea that there may be a relationship between hospitalization and the presence of vasculitis, short disease duration, glomerulonephritis, neurological involvement, hepatic involvement, and hyper viscosity [ 10 ]. It was also reported that hospitalization was encountered among pSS patients with renal involvement [ 25 ]. In our study, the prevalence of extra-glandular involvement, pulmonary involvement, or urinary system involvement was higher in the patients who were hospitalized (Table 2 ).…”

One year in review 2021: Sjögren's syndrome

“…Although the risk of ESRD did not increase in patients in comparison to non-SS controls, a significantly increased risk of long-term CKD was observed in SS patients, in particular in females. Similarly, a retrospective analysis of 437 patients included in the Spanish Sjögrenser registry, showed that CKD develops in about 60% of patients, thus suggesting the importance of regular monitoring for renal complications in patients with SS (84) . Finally, articular and digestive tract involvement in SS patients have been recently investigated.…”

Machine learning based on metabolomics reveals potential targets and biomarkers for primary Sjogren’s syndrome

“…Frontiers in Molecular Biosciences frontiersin.org Discussion Primary Sjogren's syndrome is among the most common autoimmune diseases, affecting about 0.1-0.4% of the general population, especially in women, with a prevalence comparable to that of rheumatoid arthritis (Voulgarelis and Tzioufas, 2010). In addition to the most common salivary and lacrimal gland involvement, pSS may affect several organs, including the lungs, heart, liver, nervous system, kidneys, and joints, thus severely reducing the patients' quality of life (Bak et al, 2017;Narvaez et al, 2020;Zhao et al, 2020). Metabolomics, as an emerging strategy, is an effective method for detecting and monitoring various diseases.…”