Renal involvement in human parvovirus B19 infection

Watanabe, Toru

doi:10.1007/s00467-003-1232-z

Cited by 12 publications

(10 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…If rhabdomyolysis occurs, inpatient monitoring is indicated for early recognition and treatment of complications such as acute renal failure, electrolyte disturbances, or compartment syndrome. Watanabe et al [43] recently observed that rhabdomyolysis is the most frequently reported cause of renal injury in children with influenza A infection. Rhabdomyolysis has been reported more frequently in girls a interval between the onset of influenza-like illness and the onset of symptoms associated with IAM; b diagnosis was made by serology and detection of virus in ten and five cases; c the total number of complications listed exceeds the number of patients, because some patients suffered from more than one complication Table 2 Case characteristics of 39 children with influenza-associated myositis (IAM) reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

Influenza-Associated Myositis in Children

et al. 2004

View full text Add to dashboard Cite

Background: Influenza-associated myositis (IAM) is an infrequent and poorly known complication of influenza virus infection in children. The aim of this study was to describe five cases of IAM and to review the literature on IAM in children. Patients and Methods:We conducted a retrospective analysis of cases of IAM diagnosed at two university children's hospitals in Switzerland during two consecutive influenza seasons. Findings were compared with 39 individual case reports and five publications summarizing an additional 272 cases identified by a medical online library (MEDLINE) search. Results: Overall, 316 cases were analyzed. IAM typically occurred in school-aged children with a 2:1 male predominance. Influenza B and A viruses were identified in 76% and 24% of cases, respectively. The median interval between onset of influenza and onset of IAM was 3 days (range 0-18). The calf muscles were involved alone or together with other muscle groups in 69% and 31% of cases, respectively. Blood creatine phosphokinase (CPK) concentration was invariably elevated. Median duration to clinical recovery was 3 days (range 1-30). Rhabdomyolysis occurred in ten of 316 patients (3%), was more common in girls (80%), more often associated with influenza A (86%), and led to renal failure in eight patients (80%). Conclusion: Clinical and laboratory findings of IAM are highly characteristic and allow a rapid diagnosis during the influenza season.

show abstract

Section: Discussionmentioning

confidence: 99%

Influenza-Associated Myositis in Children

et al. 2004

View full text Add to dashboard Cite

show abstract

“…indicated that severe influenza can be associated with disseminated intravascular coagulation [26]. In addition, mice infected with a nonlethal dose of influenza A displayed a rise in plasma TATc levels o4 days after infection, indicating coagulation activation at the systemic level [7].…”

Section: Respiratory Infectionsmentioning

confidence: 99%

Factor V Leiden mutation does not affect coagulopathy or outcome in lethal H1N1 influenza

Schouten

Sluijs²,

Roelofs³

et al. 2010

European Respiratory Journal

View full text Add to dashboard Cite

Influenza A is a major cause of mortality. Knowledge on coagulation activation in influenza infection is limited. The factor V Leiden (FVL) mutation is possibly subject to positive selection pressure. It is unknown whether this mutation impacts on the outcome of severe influenza. In the present study, the effect of lethal influenza on pulmonary and systemic coagulation activation and whether or not FVL mutation alters coagulation activation in and the course of lethal influenza, was determined.Wild-type mice, and mice heterozygous or homozygous for FVL were infected intranasally with a lethal dose of H1N1 (haemagglutinin 1 and neuraminidase 1) influenza A. Mice were sacrificed after 48 or 96 h for determination of coagulation activation, histopathology, pulmonary inflammatory parameters and viral load, or were observed in a survival study.Extensive local and systemic coagulation activation during lethal influenza was demonstrated by increased lung and plasma levels of thrombin-antithrombin complexes and fibrin degradation products, and by pulmonary fibrin deposition. FVL mutation did not influence the procoagulant response, lung histopathology or survival. FVL mice demonstrated elevated viral loads 48 h after infection.In conclusion, coagulation is activated locally and systemically during lethal murine influenza A infection. The FVL mutation does not influence coagulation activation, lung inflammation or survival in lethal influenza A.

show abstract

“…Our paediatric patient presented with urine abnormalities indicating nephritis. Notably, the association of parvovirus B19 infection with acute postinfectious glomerulonephritis has been earlier described in previously healthy children [1,7,12] and in children with sickle cell disease . Besides acute nephritic syndrome, clinical characteristics of previous case reports included systemic oedema and hypocomplementaemia [8] .…”

Section: Case Reportmentioning

confidence: 83%

Renal Complications Associated with Human Parvovirus B19 Infection in Early Childhood

C¹,

Herz²,

Vieth³

et al. 2007

Klin Padiatr

View full text Add to dashboard Cite

A previously healthy two-year-old girl presented with proteinuria and macroscopic haematuria. Laboratory findings included haemolytic anaemia with thrombocytopenia. Interestingly, continuing reticulocytopenia was noted. Therefore an acute parvovirus B19 infection was suspected, which could be confirmed by serological and molecularbiological evidence. This case report underlines renal complications of parvovirus B19 infection in early childhood including haemolytic-uraemic syndrome (HUS)-like episodes, and potential pathogenetic mechanisms are discussed.

show abstract

Renal involvement in human parvovirus B19 infection

Cited by 12 publications

References 12 publications

Influenza-Associated Myositis in Children

Influenza-Associated Myositis in Children

Factor V Leiden mutation does not affect coagulopathy or outcome in lethal H1N1 influenza

Renal Complications Associated with Human Parvovirus B19 Infection in Early Childhood

Contact Info

Product

Resources

About