Renal involvement in children and adolescents with inflammatory bowel disease

Abstract

PurposeThe incidence of inflammatory bowel disease (IBD) is rapidly increasing, and several reports have described the renal complications of IBD. We sought to evaluate the clinical manifestations of renal complications in children with IBD in order to enable early detection and prompt treatment of the complications.MethodsWe retrospectively reviewed the medical records of 456 children and adolescents aged <20 years who had been diagnosed with IBD since 2000. We analyzed patient age, sex, medication use, IBD disease activity, and clinical manifestations of renal symptoms.ResultsOur study comprising 456 children with IBD included 299 boys (65.6%) and 157 girls (34.4%). The study included 346 children with Crohn disease and 110 children with ulcerative colitis. The incidence of kidney-related symptoms was 14.7%, which was significantly higher than that in normal children. We observed 26 children (38.8%) with isolated hematuria, 30 children (44.8%) with isolated proteinuria, and 11 children (16.4%) with hematuria and concomitant proteinuria. A renal biopsy was performed in 7 children. Histopathological examination revealed immunoglobulin A nephropathy in 5 children (71.4%). All children presented with mild disease and well-controlled disease activity of IBD.ConclusionChildren with IBD are more likely to show kidney-related symptoms than healthy children and adolescents are. Therefore, regular screening of urine and evaluation of renal function in such children are necessary for early detection of renal complications.

Prevalence and Etiologies of Renal and Urinary Manifestations in a Large Cohort of Children With Inflammatory Bowel Disease

“…In our pediatric cohort, RUM accounted for 3.9%, which was lower than in a recent Korean pediatric study (14.7%) and also lower than in adult patients (4%–23%) (1,21). We found that patients with severe disease (intestinal resection, anti‐TNFα use) were at high risk for RUM.…”

Different renal manifestations associated with very early onset pediatric inflammatory bowel disease: case report and review of literature

“…IgA nephropathy is the most common renal manifestation in patients affected by IBD. Other types of glomerulonephritis in IBD, including membrano-proliferative glomerulonephritis, minimal change disease, membranous nephropathy, anti-glomerular basement membrane glomerulonephritis and C3 glomerulopathy have been only rarely reported and cannot be considered as potential associations [ 12 , 13 , 17 ].…”

miR-30c-5p Reduces Renal Ischemia-Reperfusion Involving Macrophage

“…In addition, the intake of IL-10 prolonged allograft rejection times and protected allografts [24]. A recent study reported that IL-4 polymorphisms were correlated with inflammatory bowel disease (IBD) [25], and patients with IBD were more likely to have kidney-related symptoms, including microscopic hematuria and proteinuria [26]. In our study, I/R caused rat kidney tissue to have lower expression of IL-4 and IL-10, and miR-30c-5p agomir reduced I/R injury in accordance with improvement of IL-4 and IL-10 (Figure 2).…”