Renal Insufficiency Due to Paroxysmal Cold Hemoglobinuria

The Pathogenesis of Acute Renal Failure Associated With Traumatic and Toxic Injury. Renal Ischemia, Nephrotoxic Damage and the Ischemuric Episode 1

“…Our material was obtained from a case of paroxysmal hemoglobinuria reported by Drs. Ralph Sussman and Herbert Kayden (20). After 11 typical attacks over a period of two years, an extraordinarily severe seizure resulted in oliguria and nitrogen retention with death on the 12th day.…”

Effect of Urinary Alkalinization on Renal Changes Produced by Cationic Albumin

“…Disturbances of renal function and structure produced by proteins and other macrom olecules have been observed in clinical practice and have been extensively studied experimentally [3][4][5][6][7][8][9]. The fact that this damage is usually produced by molecules that are cationic or slightly anionic in relation to plasma suggests that the electric charge of these molecules may play a role in the development of this damage.…”

Renal Impairment in Patients with Paroxysmal Nocturnal Hemoglobinuria

“…Shioji et al (1974) asserted that alteration in renal hemodynamics may be a predisposing factor as the cause of tubular dysfunction in patients with nephrotic syndrome. The observation about paroxysmal cold hemoglobinuria with renal insufficiency by Sussman and Kayden (1948) suggested diminished renal blood flow with vasoconstriction as one of the mechanism of renal damage . On the other hand, Bradley and Bradley (1947) mentioned that renal vasoconstriction with great reduction of effective blood flow occurred in severe chronic anemia.…”