Renal hypouricaemia in insulin treated diabetes mellitus

Gotfredsen, Anders; McNair, Peter; Christiansen, Claus; Transbøl, Ib

doi:10.1016/0009-8981(82)90376-x

Cited by 31 publications

(31 citation statements)

References 17 publications

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“…CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; FE-Na, fractional excretion of sodium; FE-Ua, fractional excretion of uric acid. patients with type 2 diabetes and glycosuria in our cohort (42,43). Glycosuria may also inhibit the activity of the TAL and consequently, lower uromodulin excretion (44).…”

Section: Discussionmentioning

confidence: 94%

Clinical, Genetic, and Urinary Factors Associated with Uromodulin Excretion

Troyanov

Delmas-Frenette

Bollée

et al. 2016

Clinical Journal of the American Society of Nephrology

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Background and objectives The urinary excretion of uromodulin is influenced by common variants in the UMOD gene, and it may be related to NaCl retention and hypertension. Levels of uromodulin are also dependent of the renal function, but other determinants remain unknown.Design, setting, participants, & measurements We tested associations between the urinary excretion of uromodulin; medical history and medication; serum and urinary levels of electrolytes, glucose, and uric acid; and the genotype at the UMOD/Protein Disulfide Isomerase-Like, Testis Expressed locus (rs4293393 and rs12446492); 943 participants from the CARTaGENE Cohort, a random sample from the Canadian population of 20,004 individuals, were analyzed. Participants with available genotyping were obtained from a substudy addressing associations between common variants and cardiovascular disease in paired participants with high and low Framingham risk scores and vascular rigidity indexes.Results The population studied was 5469 years old, with 51% women and eGFR of 9614 ml/min per 1.73 m 2 . Uromodulin excretion was 25 (11-42) mg/g creatinine. Using linear regression, it was independently higher among patients with higher eGFR, the TT genotype of rs4293393, and the TT genotype of rs12446492. The fractional excretions of urate and sodium showed a strong positive correlation with uromodulin, likely linked to the extracellular volume status. The presence of glycosuria and the use of uricosuric drugs, which both increased the fraction excretion of urate, were independently associated with a lower uromodulin excretion, suggesting novel interactions between uric acid and uromodulin excretion. ConclusionsIn this large cohort, the excretion of uromodulin correlates with clinical, genetic, and urinary factors. The strongest associations were between uric acid, sodium, and uromodulin excretions and are likely linked to the extracellular volume status.

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Section: Discussionmentioning

confidence: 94%

Clinical, Genetic, and Urinary Factors Associated with Uromodulin Excretion

Troyanov

Delmas-Frenette

Bollée

et al. 2016

Clinical Journal of the American Society of Nephrology

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“…Hyperuricemia has been attributed to biochemical abnormalities found in obesity-hypertension-hypercholesterolemia-hyperuricemia syndrome as part of both diabetic and pre-diabetic conditions. 18 concluded that low level of uric acid in severe hyperglycemia has been attributed to the uricosuric effect of glycosuria, which might be an explanation of the low uric acid concentration among overt diabetic patients. Furthermore, uric acid concentration might be influenced by the changes in plasma glucose and insulin concentrations.…”

Section: Discussionmentioning

confidence: 99%

A Cross Sectional Study Showing Association of Serum Uric Acid in PreDiabetic and Diabetic Indian Population

Sachan¹

2018

jmscr

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“…Additionally, uric acid has been found as the main component of stones in a significantly higher proportion of patients with T2DM [19]. Studies have shown that uric acid excretion is increased in the setting of hyperglycemia and glycosuria, a mechanism which may account for the increased formation of uric acid stones among diabetics [20,21]. (Figure 2) Previous studies have evaluated the effect of metabolic syndrome [22] and T2DM on kidney stone disease.…”

Section: Discussionmentioning

confidence: 99%