Renal hemodynamics and sodium excretion in stroke-prone spontaneously hypertensive rats

Nagaoka, Akinobu; Kakihana, Mitsuru; Suno, Masahiro; Hamajo, Kazuhiro

doi:10.1152/ajprenal.1981.241.3.f244

Cited by 20 publications

(29 citation statements)

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“…4546 The finding of higher hematocrit values in SHR, when compared with WKY rats at age 8, 12, and 16 weeks, suggests a lower plasma volume in the hypertensive group. This finding has been previously reported, 42 but whether there is a plasma volume difference between SHR and WKY rats is highly controversial. 43 In agreement with earlier results, 13 we now report that the ANF content of the right atrium of prehypertensive SHR (4 weeks) is higher than in both normotensive groups.…”

Section: Discussionsupporting

confidence: 82%

“…The decrease in renal perfusion pressure in SHR to normal levels abolishes the exaggerated natriuretic response to a stimulus of ANF release, 17 an acute sodium load. 40 - 42 The decrease in the natriuretic response to ANF or to a sodium load in SHR with normal renal perfusion pressure could be mediated in part by the lower density of glomerular ANF receptors.…”

Section: Discussionmentioning

confidence: 99%

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Glomerular atrial natriuretic factor receptors in spontaneously hypertensive rats.

et al. 1989

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There are differences in the renal handling of sodium between spontaneously hypertensive rats (SHR) and their normotensive controls. We investigated whether this difference may be associated with changes in plasma and tissue atrial natriuretic factor (ANF) levels and with alterations in glomerular ANF receptors at 4, 8, 12, and 16 weeks of age. Age-matched Wistar-Kyoto (WKY) and Wistar rats were used as normotensive controls. Systolic blood pressure was higher in SHR at 8, 12, and 16 weeks, and cardiac hypertrophy was also present in these animals at 4 weeks. Plasma ANF C-and N-terminal concentrations were greater than in both normotensive groups at 8 and 16 weeks. ANF in the right atrium was higher in SHR than in WKY rats and identical to that in the Wistar group at 4 and 8 weeks. ANF in the left atrium was lower in SHR than in both control groups at week 12. No differences were found in ventricular ANF content. The density of glomerular ANF binding sites increased with age in WKY and Wistar rats but not in SHR. At weeks 8, 12, and 16, both normotensive groups had a higher density of binding sites than SHR, but binding site affinity was greater in SHR at weeks 8 and 12. After incubation with increasing concentrations of ANF, the production of cyclic guanosine monophosphate (cGMP) by isolated glomeruli from 16-week-old rats was lower in SHR than in both normotensive groups. We conclude that the development of hypertension in SHR is associated with higher plasma ANF levels and decreased glomerular ANF receptor density and glomerular cGMP production. Through modulation of ANF glomerular receptors, ANF in SHR, when compared with normotensive counterparts, may contribute to the difference in renal sodium handling. (Hypertension 1989; 13:567-574)

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Glomerular atrial natriuretic factor receptors in spontaneously hypertensive rats.

et al. 1989

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“…In the groups with aortic constriction, the clamp was constricted to maintain the mean arterial pressure at approx. 100 mmHg, the average pressure of normal rats (12). In the other groups, the same operation procedure was performed, but the clamp was not constricted.…”

Section: Methodsmentioning

confidence: 99%

“…However, renal sodium and water excretion in SHR was normal in the hypertensive stage (11,12). This is true of the stroke-prone strain of SHR (12) established by Okamoto et al (13).…”

mentioning

confidence: 90%

“…This is true of the stroke-prone strain of SHR (12) established by Okamoto et al (13). However, a reduced ability of SHR and stroke-prone SHR (SHRSP) to excrete sodium and water could be demon strated by reducing the renal perfusion pressure to a level similar to that of control Wistar Kyoto rats (12,14). The purpose of the present experiments was to investigate whether renal sympathetic activity contri butes to the decreases in renal sodium and water excretion in SHRSP that are observed when the renal perfusion pressure is nor malized.…”

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confidence: 93%

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Effects of renal sympathectomy on sodium and water excretion in stroke-prone spontaneously hypertensive rats.

Nagaoka

Kakihana

1982

Jpn.J.Pharmacol

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Abstract-In stroke-prone spontaneously hypertensive rats (SHRSP), urinary excretion of sodium and water and glomerular filtration rate (GFR) are markedly decreased by acute normalization of the renal perfusion pressure using an aortic clamping technique.To examine the mechanism for the decreased sodium and water excretion, SHRSP rats were subjected to bilateral renal denervation.Sodium and water excretion and GFR in SHRSP with aortic clamping were significantly restored by the renal dener vation. The restoration was more prominent in the urine flow and GFR. When renal perfusion pressure was normalized by administration of sympa tholytic drugs in another group of SHRSP, sodium and water excretion were decreased.However, the extent of the decrease in urine flow but not in sodium excretion was significantly less than that in SHRSP with aortic constriction.GFR was not changed by administration of the sympatholytic drugs.Renal denervation lowered the blood pressure in SHRSP. These results suggest that renal sympathetic nerve activity is greatly involved in the reduced water excretion and partly involved in the reduced sodium excretion in SHRSP rats.

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Genetic models of arterial hypertension ? role of tubular ion transport

et al. 1993

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The description of pathogenetic mechanisms underlying different genetic models of essential hypertension is a useful way of illustrating the logical sequence needed to dissect a complex phenotypic condition such as hypertension. The abnormalities in renal function observed in spontaneously hypertensive rats of the Okamoto strain and Milan strain will be emphasized. The description may proceed "downward" from alterations that affect the whole body function to cellular and subcellular levels. However, the identification in the Milan strain rats of a point mutation in the gene coding for adducin, a skeletal protein able to modulate transepithelial sodium transport, provides the opportunity to reconstruct, in an "upward" direction, the sequence of events leading from the single point mutation to the final complex phenotype of essential hypertension.

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Renal hemodynamics and sodium excretion in stroke-prone spontaneously hypertensive rats

Cited by 20 publications

References 0 publications

Glomerular atrial natriuretic factor receptors in spontaneously hypertensive rats.

Glomerular atrial natriuretic factor receptors in spontaneously hypertensive rats.

Effects of renal sympathectomy on sodium and water excretion in stroke-prone spontaneously hypertensive rats.

Genetic models of arterial hypertension ? role of tubular ion transport

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