Renal hemodynamics and oxygenation in transient renal artery occluded rats evaluated with iron-oxide particles and oxygenation-sensitive imaging

Pedersen, Michael; Laustsen, Christoffer; Pérot, Vinçent; Basseau, F; Moonen, C.; Grenier, N.

doi:10.1016/j.zemedi.2010.02.002

Cited by 20 publications

(15 citation statements)

References 24 publications

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“…A study that investigated the ambilateral RBF of rats with unilateral arterial occlusion (RAS) was performed by Pedersen et al [46] who measured hemodynamic parameters of the kidney by dynamic susceptibility weighted (DSC) – MRI using ultra small superparamagnetic iron oxide (USPIO). Overall the data of 14 animals were acquired in that study and led to a mean cortical RBF of 431 ml/100 g/min and 410 ml/100 g/min in the healthy and RAS kidneys, respectively.…”

Section: Discussionmentioning

confidence: 99%

Quantitative Renal Perfusion Measurements in a Rat Model of Acute Kidney Injury at 3T: Testing Inter- and Intramethodical Significance of ASL and DCE-MRI

et al. 2013

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ObjectivesTo establish arterial spin labelling (ASL) for quantitative renal perfusion measurements in a rat model at 3 Tesla and to test the diagnostic significance of ASL and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in a model of acute kidney injury (AKI).Material and MethodsASL and DCE-MRI were consecutively employed on six Lewis rats, five of which had a unilateral ischaemic AKI. All measurements in this study were performed on a 3 Tesla MR scanner using a FAIR True-FISP approach and a TWIST sequence for ASL and DCE-MRI, respectively. Perfusion maps were calculated for both methods and the cortical perfusion of healthy and diseased kidneys was inter- and intramethodically compared using a region-of-interest based analysis.Results/SignificanceBoth methods produce significantly different values for the healthy and the diseased kidneys (P<0.01). The mean difference was 147±47 ml/100 g/min and 141±46 ml/100 g/min for ASL and DCE-MRI, respectively. ASL measurements yielded a mean cortical perfusion of 416±124 ml/100 g/min for the healthy and 316±102 ml/100 g/min for the diseased kidneys. The DCE-MRI values were systematically higher and the mean cortical renal blood flow (RBF) was found to be 542±85 ml/100 g/min (healthy) and 407±119 ml/100 g/min (AKI).ConclusionBoth methods are equally able to detect abnormal perfusion in diseased (AKI) kidneys. This shows that ASL is a capable alternative to DCE-MRI regarding the detection of abnormal renal blood flow. Regarding absolute perfusion values, nontrivial differences and variations remain when comparing the two methods.

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Section: Discussionmentioning

confidence: 99%

Quantitative Renal Perfusion Measurements in a Rat Model of Acute Kidney Injury at 3T: Testing Inter- and Intramethodical Significance of ASL and DCE-MRI

et al. 2013

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“…53 After longer periods of reperfusion in the rat (3 days), medullary oxygenation was increased despite a reduction in medullary blood flow, with no change in cortical pO 2 . 54 Hyperoxia after ischemia/ reperfusion injury may be explained if reduced oxygen consumption due to reduced Cortex Epstein et al 33 Wang et al 50 Economides et al 34 Pruijm et al 26 …”

Section: Acute Kidney Injury Ischemia Reperfusion Injurymentioning

confidence: 99%

Blood oxygenation level-dependent MRI for assessment of renal oxygenation

Neugarten¹,

Golestaneh²

2014

IJNRD

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Blood oxygen level-dependent magnetic resonance imaging (BOLD MRI) has recently emerged as an important noninvasive technique to assess intrarenal oxygenation under physiologic and pathophysiologic conditions. Although this tool represents a major addition to our armamentarium of methodologies to investigate the role of hypoxia in the pathogenesis of acute kidney injury and progressive chronic kidney disease, numerous technical limitations confound interpretation of data derived from this approach. BOLD MRI has been utilized to assess intrarenal oxygenation in numerous experimental models of kidney disease and in human subjects with diabetic and nondiabetic chronic kidney disease, acute kidney injury, renal allograft rejection, contrast-associated nephropathy, and obstructive uropathy. However, confidence in conclusions based on data derived from BOLD MRI measurements will require continuing advances and technical refinements in the use of this technique.

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“…Animal studies in a swine model show regional decreases in renal oxygenation during graded ARAS that also appear as changes in R2* signal under similar conditions [19]. Temporary renal artery occlusion in rats induces changes in medullary blood flow and reduction in R2* that persist 3 days after the event [26]. …”

Section: Bold Mri Applied To the Kidneymentioning

confidence: 99%

Blood Oxygen Level–Dependent (BOLD) MRI in Renovascular Hypertension

2011

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Establishing whether large vessel occlusive disease threatens tissue oxygenation and viability in the post-stenotic kidney is difficult for clinicians. Development of blood oxygen level–dependent (BOLD) MRI methods can allow functional evaluation of regional differences in deoxyhemoglobin levels within the kidney without requiring contrast. The complex renal circulation normally provides a gradient of oxygenation from a highly vascular cortex to much reduced levels in the deep sections of medulla, dependent upon adjustments in renal afferent arterioles, oxygen consumption related to solute transport, and arteriovenous shunting related to the juxtaposition of descending and ascending vasa recta. Studies with BOLD imaging have identified adaptation to substantial reductions in renal blood flow, volume, and glomerular filtration rate in post-stenotic kidneys that preserves medullary and cortical oxygenation during medical therapy. However, extreme vascular compromise overwhelms these adaptive changes and leads to cortical hypoxia and microvascular injury.

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Renal hemodynamics and oxygenation in transient renal artery occluded rats evaluated with iron-oxide particles and oxygenation-sensitive imaging

Cited by 20 publications

References 24 publications

Quantitative Renal Perfusion Measurements in a Rat Model of Acute Kidney Injury at 3T: Testing Inter- and Intramethodical Significance of ASL and DCE-MRI

Quantitative Renal Perfusion Measurements in a Rat Model of Acute Kidney Injury at 3T: Testing Inter- and Intramethodical Significance of ASL and DCE-MRI

Blood oxygenation level-dependent MRI for assessment of renal oxygenation

Blood Oxygen Level–Dependent (BOLD) MRI in Renovascular Hypertension

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