Renal hemodynamic and excretory effects of n‐0861, a non‐xanthine adenosine A₁‐receptor antagonist

Abstract

I Strategy, Management and Health Policy I ABSTRACTThe renal hemodynarnic and excretory effects of intravenous N-0861, a non-xanthine adenosine A,-receptor antagonist, were evaluated in conscious and anesthetized male SpragueDawley rats. In conscious rats, N-0861 (10, 30 pmol/kg, iv) significantly increased the excretion of urine, Na+, and K + ; U, , V was increased only in the rats treated with 10 FmoVkg, N-0861. The relative excretion of K + was similar to that of Na*. Lower doses of N-0861 (1,3 Fmol/kg, iv) had no effect. During clearance studies in anesthetized rats, N-0861 (3, 10, 30 pmollkg, iv) had little effect on systemic or renal hemodynamics, but provoked significant saluresis that was poorly related to dose, and that was characterized by a somewhat greater excretion of Na+ and CI-relative to K + .These results indicate that the selective adenosine A, receptor antagonist N-0861 has little influence on resting renal hernodynamics and suggest that the natriuretic responses are due to inhibition of tubular Na ' reabsorption. o