Renal Handling of Urate

Läng, Florian

doi:10.1007/978-3-642-68147-9_17

Cited by 9 publications

(1 citation statement)

References 226 publications

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“…The alterations we observed may be due to altered food intake directly or indirectly altering the renal handling of urate (Scott et al, 1963;Bell et al, 1969). The wide variety of factors influencing the renal handling of urate have been recently reviewed (Lang, 1981). The existing evidence therefore suggests that environmental factors may alter excretion to show a day/night difference but such a difference is not inherent.…”

Section: Urate Excretionmentioning

confidence: 99%

Xanthine oxidase deficiency and ‘Dalmatian’ hypouricaemia: Incidence and effect of exercise

Harkness

Coade

Walton

et al. 1983

J of Inher Metab Disea

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In order to study the effects of raising the hypoxanthine concentration in plasma on its metabolism and renal handling, the effects of intense exercise have been investigated in a patient with xanthine oxidase deficiency. Despite the 90-fold increased concentration of hypoxanthine in plasma above resting levels in normal individuals, the intracellular concentration of the initial product of hypoxanthine in cells, IMP, was unaffected. Evolution may have stabilized intracellular nucleotide concentrations against the large fluctuations in plasma hypoxanthine which occur during exercise. The renal handling of hypoxanthine is consistent with 'filtration'. In contrast, xanthine clearances may exceed those for creatinine and urinary concentrations do not correlate with those for creatinine; 'secretion' may be involved. Xanthine excretion may reflect guanine breakdown. A retrospective survey of urate concentrations in blood from 47 420 patients followed by further selected investigations detected 2 women with persistent marked hypouricaemia and high urinary urate clearances, 'Dalmatian' hypouricaemia. High pressure liquid chromatographic analysis of plasma extracts can distinguish xanthine oxidase deficiency from other causes of hypouricaemia.

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Section: Urate Excretionmentioning

confidence: 99%

Xanthine oxidase deficiency and ‘Dalmatian’ hypouricaemia: Incidence and effect of exercise

Harkness

Coade

Walton

et al. 1983

J of Inher Metab Disea

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Renal Excretion and Tubular Transport of Organic Anions and Cations

Roch-Ramel

Besseghir

Murer

1992

Comprehensive Physiology

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The sections in this article are: Organic Anions Introduction Renal Excretion and Tubular Transport of Organic Anions Mechanisms Involved in Tubular Transport of Organic Anions Conclusions on the Renal Transport of Organic Anions Organic Cations Introduction Renal Excretion and Tubular Transport of Organic Cations Mechanisms Involved in Tubular Transport of Organic Cations General Conclusions

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Purine Excretion

Greger¹

1989

Genetic and Therapeutic Aspects of Lipid and Purine Metabolism

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Renal Handling of Urate

Cited by 9 publications

References 226 publications

Xanthine oxidase deficiency and ‘Dalmatian’ hypouricaemia: Incidence and effect of exercise

Xanthine oxidase deficiency and ‘Dalmatian’ hypouricaemia: Incidence and effect of exercise

Renal Excretion and Tubular Transport of Organic Anions and Cations

Purine Excretion

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