Renal Handling of Muramidase in Patients with Kidney Diseases or Hypertension

Abstract

Jensen, H. Renal Handling of Murarnidase in Patients with Kidney Diseases or Hypertension. Scand. 1. din. Lab. Invest. 32. 11 1-1 15, 1973. By means of electrophoresis in antibodycontaining agarose gel, serum and urine rnuramidase were quantitated in 79 patients with renal disease or hypertension. In patients with a normal glornerular filtration rate, an increased urinary excretion of muramidase was found in only 3 of 33 cases. The diagnosis in these 3 cases was: Alport's syndrome (I case), hypertension from oral contraceptives (2 cases). In 46 patients with a decreased glomerular filtration rate, the urinary excretion of muramidase was increased in 29 cases. It is concluded that rnuramidasuria in chronic renal disorders is determined by the magnitude of the glomerular filtration rate and not by the aetiology of the renal disease.

Serum levels of lysozyme in term and preterm newborns.

“…Since 1922 when Fleming reported the discovery of a 'remarkable bacteriolytic element found in tissues and secretions', lysozyme (muramidase) has been studied extensively both in health (Hansen, Karle, and Andersen, 1969; Barratt and Crawford, 1970;Hansen et al, 1972;Wright and Malawista, 1972;Hansen and Andersen, 1973) and disease (Catovsky et al, 1971;Perillie et al, 1968;Weissmann, 1967;Osserman and Lawlor, 1966;Perin and Jolles, 1972;Hansen, 1973;Jensen, 1973). After the discovery that plasma lysozyme is mainly derived from disintegrating neutrophilic granulocytes (Hansen et al, 1969;Fink and Finch, 1968) this enzyme was also used in the study of leucokinetics (Hansen et al, 1969;Catovsky et al, 1971;Hansen, 1973).…”