Renal Gluconeogenesis in the Intact Dog

Cohn, Clarence; Katz, Bertram; Kolinsky, Muriel

doi:10.1152/ajplegacy.1951.165.2.423

Cited by 14 publications

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“…Our results on glucose uptake are at variance with those of Cohn, Katz & Kolinsky (1951), who found in dogs that the kidneys take up glucose, regardless of its concentration in arterial blood. There are two possible reasons which could have caused this difference: (1) R. DZTRIK AND OTHERS (2) different experimental conditions.…”

Section: Discussionsupporting

confidence: 72%

Glucose metabolism in rat kidney: influence of insulin and adrenaline

Dzúrik¹,

Krajci-Lazary²,

Niederland³

1963

The Journal of Physiology

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In previous investigations it was revealed that following the administration of toxic amounts of Salyrgan the renal glycogen concentration rises (Dziurik, Brixov'a & Kolesar, 1961). Pytasz, Zarzycki & Taborska (1960) drew attention to the fact that adrenaline does not reduce the renal glycogen concentration. Their method for the estimation of glycogen is not very specific. When repeating their experiments in our laboratory, using a more specific method, we found that adrenaline actually does not reduce the renal glycogen concentration. In some of our experiments we even found an increased renal glycogen concentration after the administration of adrenaline, despite the fact that its concentration in liver and muscle fell at the same time (Krajci-Lazairy, Dz(urik & Niederland, 1962). The explanation of these paradoxical findings is difficult. In any case they suggest a different glycogen metabolism in kidney compared with that in liver and muscle.It may be assumed that the glycogen metabolism in kidneys is related to glucose metabolism. Teng (1954) demonstrated that in kidney slices there is a direct relation between the glucose and glycogen concentrations. In the present paper we describe experiments on effects of insulin and adrenaline on renal glucose metabolism. METHODSAnimals. Male Wistar rats, weighing 150-200 g, were used. The rats were given food and water ad libitum.Adrenaline (Spofa) (50 ,ug/100 g body wt.) was administered subcutaneously, 1 hr before the withdrawal of blood samples, and insulin (Novo) (0 5 u./100 g body wt.) subcutaneously at the same time.Estimation of renal blood flow. 60 min before the withdrawal of blood samples water (5 ml./100 g body wt.) was given intraperitoneally. 25 min before the blood samples were collected para-amino-hippurate (PAH) (0-75 ml. 1-2 %/100 g) was injected subcutaneously.Urine was collected for 10-15 min. Blood was subsequently withdrawn from the renal vein and aorta under light ether anaesthesia. To prevent the development of ischaemia only 1 ml. blood was withdrawn. In order to reduce the volume of renal dead 3pace, one week before the experiment sub-total cystectomy was performed in the experimental animals.

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Section: Discussionsupporting

confidence: 72%

Glucose metabolism in rat kidney: influence of insulin and adrenaline

Dzúrik¹,

Krajci-Lazary²,

Niederland³

1963

The Journal of Physiology

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“…Effect of aldosterone oit the incorporation of acetate into liver histones Aldosterone in high concentrations has glucocorticoid activity (Schuler et al, 1954) and the kidney is capable of gluconeogenesis (Cohn et al, 1951). It was therefore decided to examine the effect of aldosterone on the liver, the other organ concerned with gluconeogenesis but not concerned with salt transport.…”

Section: Effectofantibioticson Histone Acetylationmentioning

confidence: 99%

Histone acetylation and hormone action. Early effects of aldosterone on histone acetylation in rat kidney

Libby

1973

Biochemical Journal

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Histone acetylation in the kidney of the adrenalectomized rat was increased 5 min after a physiological dose of aldosterone. The increase was exclusively in the histone F2a1. The increase in histone acetylation was given by 9alpha-fluorocortisol, deoxycorticosterone and cortisol, but not by progesterone. The increase in histone acetylation was abolished by prior treatment of the animals with the anti-mineralocorticoid agent, SC14266 [potassium 3-(3-oxo-17beta-hydroxy-4,6-androstadien-17-yl) propionate]; the basal degree of histone acetylation was unaffected. Pretreatment of the animals with actinomycin D or cyclo-heximide did not affect the stimulation, showing the stimulation was not due to increased synthesis of enzyme.

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Diabetes und Niere

Oberdisse

Irmscher

1968

Verhandlungen Der Deutschen Gesellschaft Für Innere Medizin

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Renal Gluconeogenesis in the Intact Dog

Cited by 14 publications

References 0 publications

Glucose metabolism in rat kidney: influence of insulin and adrenaline

Glucose metabolism in rat kidney: influence of insulin and adrenaline

Histone acetylation and hormone action. Early effects of aldosterone on histone acetylation in rat kidney

Diabetes und Niere

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