Renal Functions of TRP Channels in Health and Disease

Chubanov, Vladimir; Kubanek, Sebastian; Fiedler, Susanne; Mittermeier, Lorenz; Gudermann, Thomas; Dietrich, Alexander

doi:10.4324/9781315152837-10

Cited by 5 publications

(5 citation statements)

References 210 publications

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“…Inhibition of TRPCs, such as TRPC4 and TRPC5, have anxiolytic and antidepressant effects in mice, which could potentially be used for treatment of anxiety disorders ( Just et al, 2018 ). Many TRPs are also intimately connected to itching ( Tóth et al, 2015 ), cardiovascular diseases ( Watanabe et al, 2008 ; Yue et al, 2015 ), kidney diseases ( Hsu et al, 2007 ; Chubanov et al, 2017 ), diabetes ( Colsoul et al, 2013 ; Zsombok and Derbenev, 2016 ), and cancers ( Lehen’kyi and Prevarskaya, 2011 ; Santoni and Farfariello, 2011 ; Shapovalov et al, 2016 ; Yang and Kim, 2020 ).…”

Section: Pathological and Therapeutic Roles Of Trp Channelsmentioning

confidence: 99%

Targeting TRP channels: recent advances in structure, ligand binding, and molecular mechanisms

Huang,

Korsunsky,

Yazdani

et al. 2024

Front. Mol. Neurosci.

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Transient receptor potential (TRP) channels are a large and diverse family of transmembrane ion channels that are widely expressed, have important physiological roles, and are associated with many human diseases. These proteins are actively pursued as promising drug targets, benefitting greatly from advances in structural and mechanistic studies of TRP channels. At the same time, the complex, polymodal activation and regulation of TRP channels have presented formidable challenges. In this short review, we summarize recent progresses toward understanding the structural basis of TRP channel function, as well as potential ligand binding sites that could be targeted for therapeutics. A particular focus is on the current understanding of the molecular mechanisms of TRP channel activation and regulation, where many fundamental questions remain unanswered. We believe that a deeper understanding of the functional mechanisms of TRP channels will be critical and likely transformative toward developing successful therapeutic strategies targeting these exciting proteins. This endeavor will require concerted efforts from computation, structural biology, medicinal chemistry, electrophysiology, pharmacology, drug safety and clinical studies.

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Section: Pathological and Therapeutic Roles Of Trp Channelsmentioning

confidence: 99%

Targeting TRP channels: recent advances in structure, ligand binding, and molecular mechanisms

Huang,

Korsunsky,

Yazdani

et al. 2024

Front. Mol. Neurosci.

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show abstract

“…TRPs in the urinary system TRPC1, TRPC3, TRPC5 and TRPC6 are reportedly involved in kidney disorders (Chubanov et al, 2017), including diabetic nephropathy and kidney fibrosis (Saliba et al, 2015). Whereas TRPC5 and TRPC6 may play roles in acquired and inherited FSGS, TRPC5 has been proposed to be a target for acquired FSGS (Pablo and Greka, 2019;Zhou et al, 2017).…”

Section: Trps In Respiratory Disordersmentioning

confidence: 99%

TRP channels in health and disease at a glance

Yue

2021

Journal of Cell Science

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The transient receptor potential (TRP) channel superfamily consists of a large group of non-selective cation channels that serve as cellular sensors for a wide spectrum of physical and environmental stimuli. The 28 mammalian TRPs, categorized into six subfamilies, including TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin) and TRPP (polycystin), are widely expressed in different cells and tissues. TRPs exhibit a variety of unique features that not only distinguish them from other superfamilies of ion channels, but also confer diverse physiological functions. Located at the plasma membrane or in the membranes of intracellular organelles, TRPs are the cellular safeguards that sense various cell stresses and environmental stimuli and translate this information into responses at the organismal level. Loss- or gain-of-function mutations of TRPs cause inherited diseases and pathologies in different physiological systems, whereas up- or down-regulation of TRPs is associated with acquired human disorders. In this Cell Science at a Glance article and the accompanying poster, we briefly summarize the history of the discovery of TRPs, their unique features, recent advances in the understanding of TRP activation mechanisms, the structural basis of TRP Ca2+ selectivity and ligand binding, as well as potential roles in mammalian physiology and pathology.

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“…Like their nearly ubiquitous presence throughout the body, the TRP channels are widely distributed in mammalian kidneys in glomerular, tubular, and vascular cells ( Carlstrom et al, 2015 ; Chubanov et al, 2017 ; Tomilin et al, 2016 ). Glomerular mesangial cells (GMCs) express TRPC channels and modulate cell surface area, proliferation, and survival ( Adebiyi, 2014 ; Graham et al, 2007 ; Kong et al, 2015 ; Meng et al, 2014 ; Soni and Adebiyi, 2016 , 2017 ; Sours et al, 2006 ; Wang et al, 2004 ).…”

Section: Introductionmentioning

confidence: 99%

Renal vascular TRP channels

Kanthakumar

Adebiyi

2021

Current Research in Physiology

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Members of the transient receptor potential (TRP) channels that are expressed in the kidney have gained prominence in recent years following discoveries of their role in maintaining the integrity of the filtration barrier, regulating tubular reabsorption of Ca 2+ and Mg 2+ , and sensing osmotic stimuli. Furthermore, evidence has linked mutations in TRP channels to kidney disease pathophysiological mechanisms, including focal segmental glomerulosclerosis, disturbances in Mg 2+ homeostasis, and polycystic kidney disease. Several subtypes of TRP channels are expressed in the renal vasculature, from preglomerular arteries and arterioles to the descending vasa recta. Although investigations on the physiological and pathological significance of renal vascular TRP channels are sparse, studies on isolated vessels and cells have suggested their involvement in renal vasoregulation. Renal blood flow (RBF) is an essential determinant of kidney function, including glomerular filtration, water and solute reabsorption, and waste product excretion. Functional alterations in ion channels that are expressed in the endothelium and smooth muscle of renal vessels can modulate renal vascular resistance, arterial pressure, and RBF. Hence, renal vascular TRP channels are potential therapeutic targets for the treatment of kidney disease. This review summarizes the current knowledge of TRP channel expression in renal vasculature and their role in controlling kidney function in health and disease.

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Renal Functions of TRP Channels in Health and Disease

Cited by 5 publications

References 210 publications

Targeting TRP channels: recent advances in structure, ligand binding, and molecular mechanisms

Targeting TRP channels: recent advances in structure, ligand binding, and molecular mechanisms

TRP channels in health and disease at a glance

Renal vascular TRP channels

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