Renal Function Studies in Renal Carcinoma

Abstract

1. In ten patients with renal cell carcinoma (Grawitz tumour) a selective kidney function study was performed with the intention of measuring the effect of the tumour upon the function of the parenchyma surrounding the tumour.2. The excretion fraction of sodium and chloride and the osmolal clearance per unit of glomerular filtrate were significantly less and the urinary concentration of inulin and para-amino-hippuric acid were significantly greater in the affected than in the non-affected kidneys. In three patients with poorly vascularized tumours the difference between the affected and the non-affected kidney was insignificant or small.3. The findings indicate hypoperfusion of the parenchyma surrounding the tumour. The hypoperfusion may be caused by diversion of circulating blood from the parenchyma to the tumour.4. There was no correlation between the occurrence and degree of hypoperfusion and the blood pressure.

The Effect of Furosemide on the Function of Normal and Diseased Kidneys in Patients With Unilateral Pyelonephritis

“…In Fig. 1 the free water clearance has been correlated with the osmotic clearance of the same individual; earlier data of normal human kidneys investigated by an identical technique, but without injection of furosemide (35,371, and data from an investigation of nonanesthetized dogs (43), have been included. When compared with the kidney function of non-injected individuals in water diuresis, the free water clearance at corresponding osmotic clearance was reduced in all kidneys after the injection of furosemide.…”

Dye Dilution Technique with Angiography in the Investigation of Renal Arteriovenous Shunting

“…If the parenchymatous flow be restituted, whether by spontaneous coagulation or by operation of the fistula, an improved total function is to be expected. OFSTAD & KOLSAKER (1970) demonstrated by angiography a prolonged appearance time and a decreased concentration of contrast medium in the parenchyma in renal carcinoma. LINGARDH & LUNDSTROM (1971) reported a prolonged appearance time by means of a dye dilution technique in a case of adenocarcinoma and attributed this to hypoperfusion of the renal parenchyma.…”