Renal function is similar in solitary kidneys from patients with and without diabetes

Gluhovschi, Cristina; Gluhovschi, Gheorghe; Gădălean, Florica; Velciov, Silvia; Petrică, Ligia; Timar, Bogdan; Kaycsa, Adriana; Timar, Romulus

doi:10.1016/j.nefro.2016.09.019

Cited by 1 publication

(3 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, in this study we found significantly higher cardiovascular abnormalities in SaSK with DM versus patients only with DM (i.e. higher prevalence of arterial hypertension and coronary artery disease) [19].…”

Section: Diabetes Mellitussupporting

confidence: 56%

“…We observed that individuals with SK presented significantly higher proteinuria, but there were no differences regarding eGFR [19]. We concluded that there is a higher degree of renal injury in SaSK diabetic patients than in patients only with DM, even if this phenomenon is not reflected in the eGFR levels [19]. Furthermore, in this study we found significantly higher cardiovascular abnormalities in SaSK with DM versus patients only with DM (i.e.…”

Section: Diabetes Mellitussupporting

confidence: 43%

“…Consistent with these data are the findings of a recent study performed by our team, in which we compared 84 SaSK patients with DM versus 84 patients only with DM. We observed that individuals with SK presented significantly higher proteinuria, but there were no differences regarding eGFR [19]. We concluded that there is a higher degree of renal injury in SaSK diabetic patients than in patients only with DM, even if this phenomenon is not reflected in the eGFR levels [19].…”

Section: Diabetes Mellitusmentioning

confidence: 59%

See 2 more Smart Citations

The Inter-Relation between Solitary Kidney and Diabetes Mellitus-What Patterns are Known?

Milaş¹

2021

IOD

View full text Add to dashboard Cite

Over the last 20 years, most of the studies regarding the kidney outcome of people with solitary kidney (SK) show that there is a progressive loss of renal function in these individuals. In order to carry out the renal work undertaken by two kidneys, SK must adapt through complex phenomena of hypertrophy and hyperfiltration. The adaptive changes are considered, "the first hit" of SK because these lead to glomerular injury with progressive loss of kidney function. Thus, more than 50% of children with congenital SK have markers of renal injury by the age of 18 years. Also, living kidney donors have 3 to 5 times higher relative risk of end stage renal disease (ESRD as compared with their counterparts with two kidneys. A "second hit", such as obesity, hypertension, and diabetes mellitus (DM), which superimpose to the SK status conducts to a faster decline in kidney function and to a poor renal prognosis of these individuals. Due to the fact that type 2 DM is a pandemic disease of the 21st century, with an increasing prevalence among SK patients, in this paper we aimed to present different patterns of the inter-relation between SK and DM.

show abstract

Section: Diabetes Mellitussupporting

confidence: 56%

Section: Diabetes Mellitussupporting

confidence: 43%

Section: Diabetes Mellitusmentioning

confidence: 59%

See 1 more Smart Citation

The Inter-Relation between Solitary Kidney and Diabetes Mellitus-What Patterns are Known?

Milaş¹

2021

IOD

View full text Add to dashboard Cite

show abstract

Renal function is similar in solitary kidneys from patients with and without diabetes

Abstract: We found a higher value of proteinuria in the study group, significant metabolic abnormalities, as well as a higher prevalence of hypertension and coronary artery disease. However, no differences with respect to GFR were found, which could have significant implications for transplantation.

Cited by 1 publication

References 9 publications

The Inter-Relation between Solitary Kidney and Diabetes Mellitus-What Patterns are Known?

The Inter-Relation between Solitary Kidney and Diabetes Mellitus-What Patterns are Known?

Contact Info

Product

Resources

About