Renal function is associated with indicators of arsenic methylation capacity in Bangladeshi adults

Abstract

Background Arsenic (As) methylation capacity in epidemiologic studies is typically indicated by the proportions of inorganic As (%InAs), monomethylarsonic acid (%MMA), and dimethylarsinic acid (%DMA) in urine as a fraction of total urinary As. The relationship between renal function and indicators of As methylation capacity has not been thoroughly investigated. Objectives Our two aims were to examine (1) associations between estimated glomerular filtration rate (eGFR) and %As metabolites in blood and urine, and (2) whether renal function modifies the relationship of blood %As metabolites with respective urinary %As metabolites. Methods: In a cross-sectional study of 375 As-exposed Bangladeshi adults, we measured blood and urinary As metabolites, and calculated eGFR from plasma cystatin C. Results In covariate-adjusted linear models, a one ml/min/1.73 m2 increase in eGFR was associated with a 0.39% increase in urinary %InAs (p<0.0001) and a mean decrease in urinary %DMA of 0.07 (p=0.0005). In the 292 participants with measurable blood As metabolites, the associations of eGFR with increased blood %InAs and decreased blood %DMA did not reach statistical significance. eGFR was not associated with urinary or blood %MMA in covariate-adjusted models. For a given increase in blood %InAs, the increase in urinary %InAs was smaller in those with reduced eGFR, compared to those with normal eGFR (p=0.06); this effect modification was not observed for %MMA or %DMA. Conclusions Urinary excretion of InAs may be impaired in individuals with reduced renal function. Alternatively, increased As methylation capacity (as indicated by decreased urinary %InAs) may be detrimental to renal function.

Kolaviron attenuated arsenic acid induced-cardiorenal dysfunction via regulation of ROS, C-reactive proteins (CRP), cardiac troponin I (CTnI) and BCL2

“…The inflammatory reactions induced by NaAsO 2 intoxication in the kidney and heart was attenuated in KV pre-treated rats. Increase inflammation and decrease in glomerular filtration rate (eGFR) following NaAsO 2 intoxication has also been reported 80 , 81 and this is in line with the present study. The mechanism of arsenic acid-induced arteriosclerosis might be through induction of inflammation and oxidative stress.…”

Urine Arsenic and Arsenic Metabolites in U.S. Adults and Biomarkers of Inflammation, Oxidative Stress, and Endothelial Dysfunction: A Cross-Sectional Study

“…2015 ; reviewed in Zheng et al. 2014 ) and, though not extensively studied, it has been hypothesized that reduced renal function may affect the distribution of As metabolites in urine ( Peters et al. 2015 ; Zheng et al.…”

Aluminum and iron doped graphene for adsorption of methylated arsenic pollutants

“…In addition to the inorganic trivalent and pentavalent forms of arsenic, this is arsenous acid [iAs III , As(OH) 3 ] and arsenic acid [iAs V , AsO(OH) 3 ], respectively, the methylated forms of arsenicals appear as part of the arsenic cycle in the environment, and from the arsenic metabolism in humans and animals [4]. The exposure to methylated arsenic containing waters is associated with alterations in the birth weight and gestational age [5], skin lesions [6], lung and bladder cancer [7], renal dysfunctions [8], among other effects on the human health. The toxicity of the water soluble trivalent species monomethylarsonous acid [MMA III , CH 3 As(OH) 2 ] and dimethylarsinous acid [DMA III , (CH 3 ) 2 AsOH] is even larger than those determined for iAs III due to the improved cellular uptake for these [9]; the cellular uptake is lower for the pentavalent forms such as monomethylarsonic acid [MMA V , CH 3 AsO(OH) 2 ] and dimethylarsinic acid [DMA V , (CH 3 ) 2 AsO(OH)] in comparison with iAs V , although their toxicity remains as dangerous in long periods, and they are also reported to be carcinogens [10].…”