Renal function in very low birth weight infants: Normal maturity reached during early childhood

Vanpée, Mireille; Blennow, Mats; Linné, Tommy; Herin, Peter; Aperia, Anita

doi:10.1016/s0022-3476(05)81916-x

Cited by 97 publications

(77 citation statements)

References 24 publications

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“…A former study in a group of 22 children born SGA demonstrated a compromised renal function early after birth, which was found to be normal when 8 of these children were reinvestigated at the age of 8 years, a finding potentially influenced by the limited follow-up. 34 If renal damage, such as calcifications, was overt early after birth, then reduced renal function persisted. 35 Two studies of subjects born with LBW, with and without further indication of SGA, found normal renal function at the age of 20 to 30 years.…”

Section: Discussionmentioning

confidence: 99%

Salt Sensitivity of Children With Low Birth Weight

et al. 2008

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Abstract-Compromised intrauterine fetal growth leading to low birth weight (Ͻ2500 g) is associated with adulthood renal and cardiovascular disease. The aim of this study was to assess the effect of salt intake on blood pressure (salt sensitivity) in children with low birth weight. White children (nϭ50; mean age: 11.3Ϯ2.1 years) born with low (nϭ35) or normal (nϭ15) birth weight and being either small or appropriate for gestational age (nϭ25 in each group) were investigated. The glomerular filtration rate was calculated using the Schwartz formula, and renal size was measured by ultrasound. Salt sensitivity was assigned if mean 24-hour blood pressure increased by Ն3 mm Hg on a high-salt diet as compared with a controlled-salt diet. Baseline office blood pressure was higher and glomerular filtration rate lower in children born with low birth weight as compared with children born at term with appropriate weight (PϽ0.05). Salt sensitivity was present in 37% and 47% of all of the low birth weight and small for gestational age children, respectively, higher even than healthy young adults from the same region. Kidney length and volume (both PϽ0.0001) were reduced in low birth weight children. Salt sensitivity inversely correlated with kidney length (r 2 ϭ0.31; Pϭ0.005) but not with glomerular filtration rate. We conclude that a reduced renal mass in growth-restricted children poses a risk for a lower renal function and for increased salt sensitivity. Whether the changes in renal growth are causative or are the consequence of the same abnormal "fetal programming" awaits clarification. Key Words: arterial hypertension Ⅲ Barker's hypothesis Ⅲ Brenner's hypothesis Ⅲ low birth weight Ⅲ salt sensitivity Ⅲ small for gestational age

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Section: Discussionmentioning

confidence: 99%

Salt Sensitivity of Children With Low Birth Weight

et al. 2008

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“…Ре-зультаты показали, что СКФ у недоношенных детей в 9 мес скорригированного возраста ниже, чем у до-ношенных аналогичного возраста. Однако в 8 лет показатели ультразвукового исследования почек, концентрационная способность почек и экскреция альбумина были в пределах нормы и не отличались от значений у доношенных [25]. Аналогичные данные были получены J. Frankfurt и соавт., которые обсле-довали недоношенных детей с года до трех лет и на-блюдали улучшение функции почек с возрастом [26].…”

Section: российский вестник перинатологии и педиатрии 2016; 61:5 Rosunclassified

“…Исследование СКФ у недоношенных детей пока-зало, что в 9 мес скорригированного возраста данный показатель ниже у недоношенных детей, чем у до-ношенных, и составляет 82±23 мл/мин/1,73 м 2 [25]. В другом исследовании у детей с очень низкой мас-сой тела в 18-30 мес скорригированного возраста СКФ также была ниже, чем у доношенных детей [37].…”

Section: российский вестник перинатологии и педиатрии 2016; 61:5 Rosunclassified

“…Такие же противоре-чивые результаты были получены у детей школьного возраста. При этом в работе J. Rodriguez-Soriano кли-ренс эндогенного креатинина у недоношенных детей школьного возраста оказался ниже, чем у доношен-ных детей, и не было выявлено статистически значи-мых различий внутри группы недоношенных детей, детей с малой массой при рождении и массой, соот-ветствующей гестационному возрасту [39,40].…”

Section: российский вестник перинатологии и педиатрии 2016; 61:5 Rosunclassified

“…Соглас-но результатам другого исследования, у 6,4% (n =5) недоношенных детей, родившихся с экстремально низкой массой тела, в возрасте 6 лет 7 мес наблюда-лось ACR более 20 мг/г без ста ти сти чес ки значимых различий при сравнении с группой доношенных детей. В возрасте 8 и 9-12 лет микроальбуминурия определялась без статистически значимых различий между группами детей с очень низкой массой тела при рождении и доношенными [39]. Таким обра-зом, начиная с возраста 5 лет и старше существен-ной разницы между группами недоношенных и до-ношенных детей по ACR в моче не было.…”

Section: российский вестник перинатологии и педиатрии 2016; 61:5 Rosunclassified

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Formation renal function in children born prematurely

Сафина¹,

Абдуллина²,

Даминова³

2016

Ross. vestn. perinatol. pediatr.

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2016; 61: 5: 166-173. DOI: 10.21508/1027 61: 5: 166-173. DOI: 10.21508/ -4065-2016 A premature baby needing resuscitation after birth, is exposed to damaging factors affecting the entire body, including the kidneys. Aim -analysis of current data on the issue of the formation of kidney function in children born prematurely. Materials and methods. The review publications domestic and foreign authors studied data from randomized clinical and epidemiological studies. Results and discussion. Events intensive care, which include mechanical ventilation, infusion therapy, parenteral nutrition, intravenous drugs, lead to an increased load on the immature kidney premature baby in the neonatal period. A special risk factor for preterm is still imperfect glomerular and tubular function, renal large capillary surface, high renal blood flow, inadequate regulation of acid-base balance and the ability to concentrate, are under the influence of external loads become insolvent. Under the influence of damaging factors on the kidney nephron deficit increases the risk of further decline in kidney function. It is assumed that no additional nephrons deficit is not negative factors leads to chronic diseases in the future. Conclusion. Analyzing conducted research on the formation of kidney function in children born prematurely, it can be assumed that children with a gestational age less than 32 weeks and weighing less than 1500 grams at birth, who are exposed to adverse environmental factors on the developing buds in the perinatal and neonatal periods. They are in the zone of risk of chronic disease of the kidneys in later life.

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Kidney Health Monitoring in Neonatal Intensive Care Unit Graduates

Starr,

Harer,

Steflik

et al. 2024

JAMA Netw Open

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ImportanceKidney disease is common in infants admitted to the neonatal intensive care unit (NICU). Despite the risk of chronic kidney disease (CKD) in infants discharged from the NICU, neither evidence- nor expert-based recommendations exist to guide clinical care after discharge.ObjectiveTo develop recommendations for risk stratification and kidney health monitoring among infants after discharge from the NICU.Evidence ReviewAt the National Institute of Health–supported Consensus Workshop to Address Kidney Health in Neonatal Intensive Care Unit Graduates meeting conducted in February 2024, a panel of 51 neonatal nephrology experts focused on 3 at-risk groups: (1) preterm infants, (2) critically ill infants with acute kidney injury (AKI), and (3) infants with critical cardiac disease. Using established modified Delphi processes, workgroups derived consensus recommendations.FindingsIn this modified Delphi consensus statement, the panel developed 10 consensus recommendations, identified gaps in knowledge, and prioritized areas of future research. Principal suggestions include risk stratification at time of hospital discharge, family and clinician education and counseling for subsequent kidney health follow-up, and blood pressure assessment as part of outpatient care.Conclusions and RelevancePreterm infants, critically ill infants with AKI, and infants with critical cardiac disease are at increased risk of CKD. We recommend (1) risk assessment at the time of discharge, (2) clinician and family education, and (3) kidney health assessments based on the degree of risk. Future work should focus on improved risk stratification, identification of early kidney dysfunction, and development of interventions to improve long-term kidney health.

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Renal function in very low birth weight infants: Normal maturity reached during early childhood

Cited by 97 publications

References 24 publications

Salt Sensitivity of Children With Low Birth Weight

Salt Sensitivity of Children With Low Birth Weight

Formation renal function in children born prematurely

Kidney Health Monitoring in Neonatal Intensive Care Unit Graduates

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