Renal Function in Patients with Hypertension Associated Congestive Cardiac Failure Seen in a Tertiary Hospital

Osuji, CU; Nwaneli, CU; Onwubere, Bjc; Onwubuya, Emmanuel Ikechukwu; Ahaneku, Gladys I.

doi:10.1155/2012/769103

Cited by 6 publications

(4 citation statements)

References 30 publications

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“…This finding supports previous studies in the United States which linked age, female sex, limited education and low income with greater prevalence of CKD (Diedra et al, 2010). The prevalence of CKD in both male and female hypertensive subjects agrees with that from a previous study by Osuji et al (2012) who found no statistical significant difference between males and females GFR values in patients with congestive heart failure. This suggests that hypertension is also a risk factor the development of CKD.…”

Section: Discussionsupporting

confidence: 89%

Pattern of renal impairment among hypertensive subjects in Umuahia, South East, Nigeria

C¹,

Agu²,

Nwachukwu³

2016

Int. J. Med. Med. Sci.

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Hypertension is a cause and consequence of chronic kidney disease (CKD). The present study investigated the patterns of renal impairment among hypertensive subjects in Umuahia, South East, Nigeria. A cross-sectional study involving 262 subjects comprising equal number of hypertensive and non-hypertensive was used. Questionnaires were administered; medical, socio-demographic and anthropometric profiles were obtained. Blood samples were taken for creatinine determination and glomerular filtration rate (GFR) was estimated using the modification of diet in renal disease (MDRD) equation. The GFR in hypertensive group was 87.4±30.2 ml/min/1.73 m 2 compared to 99.9 ±32.3 ml/min/1.73 m 2 in the non-hypertensive. In the hypertensive group, 30.5, 29.0 and 0.8% had mild, moderate and severe renal impairment respectively whereas in the non-hypertensive group, the values were 28.2, 14.5 and 0.8% respectively. The prevalence of CKD in hypertensive subjects was 29.8% while that in the non-hypertensive was 15.3%. 55.6% of male hypertensive subjects had mild to moderate renal impairment compared to 23.5% in the non-hypertensive group; the difference between hypertensive and non-hypertensive in females was not statistically significant. More females had CKD than their male counterparts. Hypertension might have increased incidence of renal impairment and prevalence of CKD in Nigeria. This underscores the need for screening for CKD in the general population.

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Section: Discussionsupporting

confidence: 89%

Pattern of renal impairment among hypertensive subjects in Umuahia, South East, Nigeria

C¹,

Agu²,

Nwachukwu³

2016

Int. J. Med. Med. Sci.

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“…Jalur NO memliki interaksi sinergistik dengan pembentukan/degradasi nukleotida siklik dan fosforilasi protein pada trombosit dan sel otot polos, yang mengatur fungsi kardiovaskular (tonus vaskular, inhibisi agregasi trombosit serta adhesi leukosit, dan pencegahan proliferasi sel otot polos). [8][9][10] Dalam beberapa tahun terakhir, neutrofilia dan lymphocytopenia relatif terbukti menjadi prediktor independen kematian pada pasien dengan gagal jantung akut. Selain itu, rasio neutrofil-ke-limfosit (NLR) diperkenalkan sebagai penanda potensial untuk menentukan inflamasi pada gangguan jantung dan nonjantung.…”

Section: Pendahuluanunclassified

“…Hipertensi dapat bermanifestasi pada disfungsi endotel, akibatnya trombosit akan teraktivasi dan mengekspresikan lebih banyak P-Selektin dan reseptor GP IIb/IIIa sehingga lebih sensitif terhadap rangsangan zat-zat agonis dibandingkan dengan trombosit pada pasien non hipertensi . 7,8 Pada penelitian ini, nilai PDW pada penderita hipertensi menunjukkan nilai P>0.05 yang berarti tidak ada perbedaan bermakna. Parameter PDW adalah penanda sederhana dan praktis serta spesifik dari aktivasi koagulasi yang digunakan untuk menentukan heterogenitas ukuran trombosit.…”

Section: Tujuanunclassified

Analisis Nilai Indeks Trombosit Dan Rasio Trombosit Limfosit Sebagai Penanda Inflamasi Glomerulus Pada Penderita Hipertensi Berbagai Derajat

Taggara

2019

Medica Arteriana (Med-Art)

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Background : Hypertension is a major risk factor for early death and cardiovascular disease (CVD), which causes at least 1.1 million deaths per year in the world. Hypertension is also called The Silent Killer because it is often found without symptoms, which if left untreated and treated will cause complications such as stroke, heart and blood vessel disease, kidney disorders and others which can ultimately lead to disability or death. Endothelial dysfunction indirectly affects platelet dysfunction which can be assessed based on platelet index and platelet lymphocyte ratio. 2,6,7Method :170 Patients with hypertension are grouped into hypertensive stage groups 1, 2 and 3. Platelet index (MPV, PDW and PCT) and lymphocyte platelet ratio are calculated based on the results of routine blood tests. Data distribution was tested by Kolmogrov-Smirnov and analyzed with the corresponding data test.Results:Platelet index namely MPV in hypertensive patients was significantly different in each degree of hypertension, grade 1 (8.92 ± 1.23), degree 2 (8.99 ± 1.63) and degree 3 (11.2 ± 4.29) with a p value = 0.003. There is a weak correlation between MPV and serum creatinine ureum levels. However, PDW and RTL values only correlate with creatinine.Conclusion:There are differences in the value of MPV in patients with hypertension of various degrees. There is a correlation between the values of MPV, PDW and RTL and creatinine which indicate inflammation of the glomerulus.

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“…Cardiorenal continuum plays an important role in the prediction of cardiovascular and renal survival [3,4]. In many clinical studies, decreasing of renal function was found in patients with arterial hypertension [5] and chronic heart failure [6]; however, the existence of mutually reinforcing pathogenetic relations has been less studied in coronary heart disease (CHD).…”

Section: Introductionmentioning

confidence: 99%

Factor Analysis of Predicting Cardiovascular Death in the Remote Period after Myocardial Revascularization

Levitskaya¹,

Батюшин²,

Головинова³

et al. 2015

Int J Biomed

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The aim of the present study was to analyze the impact of traditional and renal risk factors (RFs) on the probability of cardiovascular death in CHD patients in the remote period after myocardial revascularization (MR). Materials and Methods:The present study included 90 CHD patients (80 men and 10 women; mean age 56.1±0.9 years) with indications for MR. The prevalence of major cardiovascular RFs (old age, gender, duration of CHD, arterial hypertension, diabetes mellitus, another localization of atherosclerotic lesions, and the presence and duration of smoking) and the main echocardiographic parameters and the parameters of renal function (MAU and GFR) were assessed. Fatal cardiovascular outcomes were the only endpoint of the study.Results: Cardiovascular death (CVD) occurred in 10/12.3% patients. The studied RFs, such as the patient's age, duration of smoking, and presence of angina with low tolerance to physical stress, had a significant impact on the probability of death in CHD patients. Risk of CVD (rCVD) over a long-term period increases by 18.1% in patients with elevated levels of total cholesterol, by 16.2% in patients with stable angina pectoris class III, by 50.5% in patients with atherosclerotic lesions of lower limb and cerebral arteries, and by 69.3% in patients suffering from overweight. Left atrial size, LVPWT, and LVMI were also significant predictors of adverse cardiovascular prognosis. The increase in the number of coronary arteries with clinically significant stenosis, including subtotal narrowing of the vessel lumen, increases rCVD in the long-term period. The important role of a highly reliable level of glucose in the urine for the risk score was found. The presence of CKD stage 3 and the impaired GFR also significantly increased rCVD.Conclusion: Our data demonstrate a high medical and social importance of a comprehensive and integrated analysis not only of traditional RFs, but also of markers of renal dysfunction in risk stratification of cardiovascular prognosis in CHD patients.

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Renal Function in Patients with Hypertension Associated Congestive Cardiac Failure Seen in a Tertiary Hospital

Cited by 6 publications

References 30 publications

Pattern of renal impairment among hypertensive subjects in Umuahia, South East, Nigeria

Pattern of renal impairment among hypertensive subjects in Umuahia, South East, Nigeria

Analisis Nilai Indeks Trombosit Dan Rasio Trombosit Limfosit Sebagai Penanda Inflamasi Glomerulus Pada Penderita Hipertensi Berbagai Derajat

Factor Analysis of Predicting Cardiovascular Death in the Remote Period after Myocardial Revascularization

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