Renal function in epidemic hemorrhagic fever

The Renal Lesion in Epidemic Hemorrhagic Fever1

“…Renal blood flow now decreases as indicated by a depression of clearances (2,3); this may occur independently of general circulatory collapse and is exaggerated when primary shock intervenes, as it did in all the cases of this series. The result of this decreased flow through the kidney is, however, quite different in case of EHF than it is in the individual with normal renal vessels who suffers a similar circulatory depression as a result, say, of surgical shock.…”

“…More recently, Hullinghorst and 1 This work was done under the auspices of the Commission on Hemorrhagic Fever, Armed Forces Epidemiological Board, and was supported by the Office of the Surgeon General of the Army, and in part by a research grant (H-1515-C2) from the National Heart Institute, of the National Institutes of Health, Public Health Service, and the Life Insurance Medical Research Fund. 2 Though the earlier reported cases of EHF were limited to Manchuria and eastern Siberia, later observations have shown that a very similar disease occurs in the Balkans and Czechoslovakia. The mild "epidemic nephropathy" observed in Finland, Sweden and Norway resembles EHF in some ways, but an identity has not been proved (5).…”

Angiography in Epidemic Nephropathy

“…Haemorrhagic fever with renal syndrome has been suggested to be a closely related condition. On the other hand, this is a more malignant nephritis, occurring, among other places, in the Far East where it caused hundreds of fatalities among American soldiers during the Korean war (ANDREW 1953, FROEB & McDOWELL 1954, DODGE et colI. 1956).…”