Renal function in a rat model of neurogenic bladder, effect of statins and phosphodiesterase-5 inhibitors

Abstract

Purpose Neurogenic bladder is a common complication of several central nervous system injuries. Statins and phosphodiesterase-5 (PDE-5) inhibitors are reportedly beneficial in neural injuries and urinary system dysfunction. The effect of simvastatin, sildenafil and tadalafil on several renal function indices of an animal model of neurogenic bladder was investigated. Methods Forty male rats were assessed in five equal groups. Dura mater and the cord were injured with an aneurysmal clamp at the level of T9-T10 in all rats except in sham group. The sham and control groups (treated by normal saline), simvastatin (4 mg/kg), sildenafil (5 mg/kg), and tadalafil (2 mg/kg) groups received treatment (i.p.) for seven consecutive days following injury. Renal system and motor functions were assessed at day 28 following injury. Data were analyzed by analysis of variance followed by the Student-Newman-Keuls post hoc test. Results Simvastatin improved both the renal and the motor function compared with the control group. However, sildenafil and tadalafil could only improve the motor function but could not make any significant differences in renal indices in comparison with the control group. Conclusion Statins can effectively improve the motor and renal functions in a condition of renal dysfunction in a rat model of neurogenic bladder. PDE-5 inhibitors could help to improve motor function, but are not helpful in renal function, at least in short time.

Reconstruction of bladder function and prevention of renal deterioration by means of end‐to‐side neurorrhaphy in rats with neurogenic bladder

“…Upper urinary tract deterioration due to NB represents the final stage of disease, which poses a challenge for treatment. However, there are few studies examined the effects of neurorrhaphy on kidney function . Our study tries to reveal some aspects of neurorrhaphy particularly its effects on restoration of bladder function in an animal model of NB.…”

“…Despite this knowledge, there are only few studies that reveal how NB affects renal morphology and function and how renal injury caused by NB can be protected in animal models. Mirzaii‐Dizgah and Salmanyan found that statins effectively improve the renal morphology and function in a condition of renal dysfunction in a rat model of NB, which is achieved through drug treatment. To our knowledge, this is the first time that end‐to‐side neurorrhaphy, a surgical procedure, is used to treat NB and attempts to prevent renal deterioration.…”

Effect of phosphodiesterase inhibitors in the bladder

“…In an animal model of neurogenic bladder, Mirzaii-Dizgah and Salmanyan [25] assessed 40 male rats divided into five equal groups. SCI was induced in all but the sham group, and renal system and motor functions were evaluated 28 days following injury.…”