Renal function impairment in Hypothyroidism

Abstract

Background: Hypothyroidism is an important public health problem in Bangladesh. It is associated with increased risk for atherosclerosis and other complications. The frank development of hypothyroidism is associated with metabolic derangements including dyslipidemia- which is an etiopathologic factor for development of renal impairment. This study was to evaluate whether hypothyroidism is associated with impaired renal function. Methods: Using a cross sectional analytical study design, a total of 111 subjects attending Out Patient Department, Center for Nuclear Medicine and Ultrasound, Bogra Medical College during January 2007 to December 2007 were included purposively. Eighty newly diagnosed hypothyroid patients (Group I) and 31 healthy adults (Group II) were enrolled in this study. Serum thyroid stimulating hormone and serum free thyroxine were assayed by radioimmunoassay. Serum fasting lipid profile, serum creatinine and serum uric acid were estimated by enzymatic colorimetric method. Estimated GFR was calculated using MDRD equation. Results: The mean (±SD) age of in Group I and Group II were 35.59 (±6.91) and 37.35 (±2.78) years and were comparable. In Group I, there were 66 females and 14 males. In Group II, there were 16 females and 15 males. The mean BMI was 25.49 ±2.17 kg/m2 in Group I and 24.24 ±1.99 kg/m2 in Group II. The mean (±SD) Serum total-cholesterol, LDL- cholesterol and tryacylglycerol in Group I were significantly higher than that in Group II. Serum HDL cholesterol in Group I was significantly lower than that in Group II (p<0.001). The mean (±SD) serum creatinine was significantly higher in Group I than Group II (P<0.001). The estimated glomerular filtration rate (eGFR) was lower in Group I compared to Group II (p=0.011). In Group I (Hypothyroid), there were significant correlations of BMI, S Total-Cholesterol, S HDLCholesterol, S LDL-Cholesterol, S triglycerides and S creatinine with serum TSH level. In Group I (Hypothyroid), there were significant positive correlations of BMI and TSH with serum creatinine. Conclusions: Hypothyroidism is associated with dyslipidemia, hyperuricemia and impaired renal function. Therefore, patients presenting with these biochemical abnormalities are recommended to be investigated for hypothyroidism and vice versa. DOI: http://dx.doi.org/10.3329/bjmb.v6i1.13283 Bangladesh J Med Biochem 2013; 6(1): 19-25

Assessment of renal function and electrolytes in patients with thyroid dysfunction, in Addis Ababa, Ethiopia: a cross sectional study

“…In the case of hypothyroidism, almost all the assessed electrolyte balance indicates a decrement; however the decrement is not statistically significant. This study finding was different from similar studies conducted by Chaudhury HS et al [ 22 ]. Decreased thyroid hormones, decreases the plasma rennin, angiotensin II, and serum angiotensin converting enzyme levels.…”

Association Between Blood Pressure, Glomerular Filtration Rate, and Serum Thyroid-Stimulating Hormone Levels in Hypothyroid Patients: A Retrospective Single-Center Study

“…A study conducted by Chaudhury et al found that patients with hypothyroidism (the case group) had a higher BMI than those in the control group. This alteration in BMI could be a reflection of decreased basal metabolic rate and direct TSH stimulation of preadipocyte differentiation, resulting in adipogenesis [ 12 ].…”

Renal function derangements in hypothyroidism: A clinical correlation between serum creatinine, urea and uric acid levels

“…Earlier, similar result for serum creatinine has also reported. 6,7 Relatively comparable changes in serum creatinine with hypothyroidism have been accounted for in segregated contextual investigations and couple of different examinations having lesser number of hypothyroid patients. 8 Indeed, even newborn children with intrinsic hypothyroidism have demonstrated higher serum creatinine levels in the extent of the seriousness of hypothyroidism, however, no impacts were seen on serum urea levels.…”