Renal Function and Urine Production in the Compromised Fetus

Fägerquist, Mats

doi:10.5772/29098

Cited by 2 publications

(2 citation statements)

References 45 publications

(66 reference statements)

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“…SD of the estimated volume can be related to the bladder volume. 25 The scatter plots demonstrated a linear relationship between SD and corresponding bladder volume for the SUM-OF-CYLINDERS but not for the VOCAL TM method, for which a quadratic regression model was used. The two regression models for the SUM-OF-CYLINDERS and VOCAL TM methods were compared using an F-test, testing for equal linear terms in the two models and zero quadratic term in the VOCAL TM model.…”

Section: Statisticsmentioning

confidence: 87%

Intra-observer repeatability when assessing the foetal urinary bladder volume by the Virtual Organ Computer-aided AnaLysis and SUM-OF-CYLINDERS methods: A pilot study

et al. 2017

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Section: Statisticsmentioning

confidence: 87%

Intra-observer repeatability when assessing the foetal urinary bladder volume by the Virtual Organ Computer-aided AnaLysis and SUM-OF-CYLINDERS methods: A pilot study

et al. 2017

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“…In humans, fetal urine formation starts during the first trimester of pregnancy (GW 10 to 11) (Abramovich, 1968). The hourly fetal urine production rate, estimated by regression analysis of bladder volumes, increases steadily during gestation (GW 20: 5 ml/h to GW 40: 51 ml/h), whereas the bladder storage interval remains unchanged (7-43 minutes) (Fagerquist, 2012). The increase in hourly fetal urine production rate is attributed to nephrogenesis and dynamic changes in RBF, GFR, tubular function, and hormonal regulation (Chevalier and Norwood, 2011).…”

Section: Functional Developmentmentioning

confidence: 99%

Ontogeny and Cross-species Comparison of Pathways Involved in Drug Absorption, Distribution, Metabolism, and Excretion in Neonates (Review): Kidney

et al. 2020

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The kidneys play an important role in many processes, including urine formation, water conservation, acid-base equilibrium, and elimination of waste. The anatomic and functional development of the kidney has different maturation time points in humans versus animals, with critical differences between species in maturation before and after birth. Absorption, distribution, metabolism, and excretion (ADME) of drugs vary depending on age and maturation, which will lead to differences in toxicity and efficacy. When neonate/ juvenile laboratory animal studies are designed, a thorough knowledge of the differences in kidney development between newborns/ children and laboratory animals is essential. The human and laboratory animal data must be combined to obtain a more complete picture of the development in the kidneys around the neonatal period and the complexity of ADME in newborns and children. This review examines the ontogeny and cross-species differences in ADME processes in the developing kidney in preterm and term laboratory animals and children. It provides an overview of insights into ADME functionality in the kidney by identifying what is currently known and which gaps still exist. Currently important renal function properties such as glomerular filtration rate, renal blood flow, and ability to concentrate are generally well known, while detailed knowledge about transporter and metabolism maturation is growing but is still lacking. Preclinical data in those properties is limited to rodents and generally covers only the expression levels of transporter or enzyme-encoding genes. More knowledge on a functional level is needed to predict the kinetics and toxicity in neonate/juvenile toxicity and efficacy studies. SIGNIFICANCE STATEMENTThis review provides insight in cross-species developmental differences of absorption, distribution, metabolism, and excretion properties in the kidney, which should be considered in neonate/juvenile study interpretation, hypotheses generation, and experimental design.dependent on the specialized subcellular structural and functional properties of renal tubule epithelium, including their various transporters, metabolic activity, and membrane integrity. Therefore, the development and maturation of these processes in pediatric patients or in animals can have a profound effect on the disposition and fate of administered drug therapies that depend on the kidney for filtration, uptake, secretion, and/or metabolism.

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Renal Function and Urine Production in the Compromised Fetus

Cited by 2 publications

References 45 publications

Intra-observer repeatability when assessing the foetal urinary bladder volume by the Virtual Organ Computer-aided AnaLysis and SUM-OF-CYLINDERS methods: A pilot study

Intra-observer repeatability when assessing the foetal urinary bladder volume by the Virtual Organ Computer-aided AnaLysis and SUM-OF-CYLINDERS methods: A pilot study

Ontogeny and Cross-species Comparison of Pathways Involved in Drug Absorption, Distribution, Metabolism, and Excretion in Neonates (Review): Kidney

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