2024
DOI: 10.3390/biomedicines12091942
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Renal Fibrosis: SIRT1 Still of Value

Huailiang Wu,
Zhen Qiu,
Liyan Wang
et al.

Abstract: Chronic kidney disease (CKD) is a major global health concern. Renal fibrosis, a prevalent outcome regardless of the initial cause, ultimately leads to end-stage renal disease. Glomerulosclerosis and renal interstitial fibrosis are the primary pathological features. Preventing and slowing renal fibrosis are considered effective strategies for delaying CKD progression. However, effective treatments are lacking. Sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase belonging to clas… Show more

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