Renal failure in patients with cirrhosis of the liver

Shear, Leroy; Kleinerman, Jerome; Gabuzda, George J.

doi:10.1016/0002-9343(65)90041-0

Cited by 181 publications

(30 citation statements)

References 34 publications

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“…Although the mechanism of the abnormal renal function was not clear, this animal model was shown to bear several close similarities to human pathophysiology observed in patients with liver disease. Thus, patients with cirrhosis of the liver may demonstrate enhanced renal reabsorption of sodium, delayed excretion of a water Received for publication 16 October 1974 and in revised form 30 December 1974. load, ascites, edema, and impaired urinary concentrating ability (4)(5)(6)(7)(8). Similar abnormalities were demonstrated in clearance studies in dogs with common bile duct ligation (3).…”

supporting

confidence: 54%

A micropuncture study of renal salt and water retention in chronic bile duct obstruction.

Bank¹,

Aynedjian²

1975

J. Clin. Invest.

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supporting

confidence: 54%

A micropuncture study of renal salt and water retention in chronic bile duct obstruction.

Bank¹,

Aynedjian²

1975

J. Clin. Invest.

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“…The latter authors attributed this decreased ( EPAEI) to possible intrarenal shunting of blood as seen in other circulations (5). Recently Schroeder et d. (6) evaluated 22 cirrhotic patients and suggested that decreased EpaH was not a consequence of decreased GFR or RPF and suggested renal cortical vasoconstriction with relative increase in medullary flow as a possible explanation of changes in renal function in cirrhotic patients.…”

mentioning

confidence: 94%

“…In many cases, histologic examination of the kidneys fails to reveal specific lesions to explain progressive azotemia and oliguria ( 2 , 3). While renal tubule function seems well preserved, reductions of glomerular filtration rate (GFR) and renal plasma flow (RPF) have been observed (4,5). Baldus et al (1) and…”

mentioning

confidence: 99%

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Failure of Cirrhotic Sera to Inhibit Renal Tubule Hippurate Transport in Vitro

Lipman

Raskin

Preuss

1969

Experimental Biology and Medicine

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Late in the course of cirrhosis, renal failure is often a complication (1, 2). In many cases, histologic examination of the kidneys fails to reveal specific lesions to explain progressive azotemia and oliguria ( 2 , 3). While renal tubule function seems well preserved, reductions of glomerular filtration rate (GFR) and renal plasma flow (RPF) have been observed (4, 5). Baldus et al. (1) and Shear et d. ( 5 ) noted reduced paraaminohippurate (PAH) extraction ratios (EPAH) in patients with cirrhosis. The latter authors attributed this decreased ( EPAEI) to possible intrarenal shunting of blood as seen in other circulations (5). Recently Schroeder et d.(6) evaluated 22 cirrhotic patients and suggested that decreased EpaH was not a consequence of decreased GFR or RPF and suggested renal cortical vasoconstriction with relative increase in medullary flow as a possible explanation of changes in renal function in cirrhotic patients. An alternative explanation for the reduced EpaH suggested by Schroeder et al. was the possible impairment of renal tubule transport of PAH either by an altered transport mechanism or a circulating substance that inhibited transport. Preuss et al. ( 7 ) have shown recently that a substance or substances present in azotemic sera inhibits PAH transport in an in vitro preparation of renal tubules. Whether such substances, which could alter hippurate transport, were also present in the sera of cirrhotics has not been reported. The purpose of this study was to determine if a substance or substances exist in cirrhotic sera that alter renal hippurate transport and thus could

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“…The kidneys appear normal at necropsy and when transplanted into noncirrhotic recipients regain their lost function (2). It is generally agreed that renal blood flow is reduced in functional renal failure but the cause of this reduction remains an enigma (3,4). A number of pharmacoIogica1 agents ( 5 ) have failed to reverse completely the basic pathophysiological defects in hepatorenal syndrome.…”

mentioning

confidence: 99%