Renal failure following cardiac transplantation

Herlitz, Hans; Lindelöw, Björn

doi:10.1093/ndt/15.3.311

Cited by 37 publications

(23 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed most studies in literature do not find a correlation between high CNI dose or trough levels in patients who do develop ESRF compared with patients who do not (2)(3)(4)(5)(7)(8)(9)(10)(11)(12). This suggests an individually determined susceptibility for the nephrotoxic effect of CNIs.…”

Section: Discussionmentioning

confidence: 98%

“…Apart from complications of immunosuppression in general, chronic treatment with CNIs more specifically may result in renal failure. The prevalence of renal dysfunction in heart transplant recipients varies from 0 to 20% in different studies (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). The disparity in reported prevalences is due to differences in the definition of renal failure as well as in the duration of follow-up after transplantation in the different studies.…”

mentioning

confidence: 99%

See 1 more Smart Citation

The Impact of Transforming Growth Factor-β1 Gene Polymorphism on End-Stage Renal Failure After Heart Transplantation

et al. 2006

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 99%

The Impact of Transforming Growth Factor-β1 Gene Polymorphism on End-Stage Renal Failure After Heart Transplantation

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Risk factors for kidney injury in this population were identified both from single-centre or registrybased studies [1][2][3][4][5][6][7][8][9][10][11][12]: pretransplant GFR, postoperative acute renal failure, recipient age, presence of diabetes mellitus, hypertension and/or dyslipidaemia, smoking, hepatitis C infection and treatment with calcineurin inhibitors (CNI).…”

Section: Introductionmentioning

confidence: 99%

Poor prognosis of heart transplant patients with end-stage renal failure

Villar

Boissonnat

Sebbag

et al. 2007

Nephrology Dialysis Transplantation

View full text Add to dashboard Cite

Background. Chronic kidney disease (CKD) and endstage renal failure (ESRF) are major complications after a heart transplant. The aim of this study is to compare survival in heart transplant (HT) vs non-heart transplant (non-HT) patients starting dialysis. Methods. Survival was studied among the 539 newly dialysed patients between 1 January 1995 and 31 December 2005 in our Department. All patients were prospectively followed from the date of first dialysis up to death or 31 December 2005. Multivariate survival analysis adjusted on baseline characteristics was performed with the Cox model. Results. There were 21 HT patients and they were younger than non-HT patients at first dialysis: 58.6 AE 11.6 vs 63.0 AE 16.2 years (P ¼ 0.09). Calcineurin inhibitor nephrotoxicity was the main cause of ESRF in HT patients (47.6%). Crude 1, 3 and 5-year survival rates in HT and in non-HT patients were as follows: 76.2%, 57.1%, 28.6% and 79.1%, 58.7%, 46.7% (P ¼ 0.2). The adjusted hazard ratio of death in HT vs non-HT patients was 2.27 [1.33-3.87], P ¼ 0.003. Sudden death was the main cause of death in HT patients, in 33.3% vs 10.4% in non-HT patients (P ¼ 0.01). Five HT patients benefited from renal transplant. They were all alive at the end of the study period, while one patient among the 16 remaining on dialysis survived. Conclusion. HT patients with CKD who reached ESRF have a poor outcome after starting dialysis in comparison with other ESRF patients. Improvement in renal function management in the case of CKD is needed in these patients and non-nephrotoxic immunosuppressive regimens have to be evaluated. Renal transplant should be the ESRF treatment of choice in HT patients.

show abstract

“…In adult heart transplant recipients, chronic renal insufficiency (CRI) and end-stage renal disease (ESRD) are well-described, with the reported incidence of ESRD (need for chronic dialysis or kidney transplant) between 2% and 10% within 5 to 15 years after transplantation. [1][2][3][4][5][6] As survival among pediatric heart transplant recipients has improved, CRI has become evident in this population also, but the incidence is unknown.…”

mentioning

confidence: 99%