Renal Failure

Wolfson, Allan B.

doi:10.1016/b978-0-323-05472-0.00095-5

Cited by 2 publications

(2 citation statements)

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“…The BCR is one of the diagnostic tools recommended to ED physicians for differentiating between PR and I AKI, yet it has never been specifically studied in this setting [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic performance of serum blood urea nitrogen to creatinine ratio for distinguishing prerenal from intrinsic acute kidney injury in the emergency department

et al. 2017

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BackgroundThe blood urea nitrogen to creatinine ratio (BCR) has been used since the early 1940s to help clinicians differentiate between prerenal acute kidney injury (PR AKI) and intrinsic AKI (I AKI). This ratio is simple to use and often put forward as a reliable diagnostic tool even though little scientific evidence supports this. The aim of this study was to determine whether BCR is a reliable tool for distinguishing PR AKI from I AKI.MethodsWe conducted a retrospective observational study over a 13 months period, in the Emergency Department (ED) of Nantes University Hospital. Eligible for inclusion were all adult patients consecutively admitted to the ED with a creatinine >133 μmol/L (1.5 mg/dL).ResultsSixty thousand one hundred sixty patients were consecutively admitted to the ED. 2756 patients had plasma creatinine levels in excess of 133 μmol/L, 1653 were excluded, leaving 1103 patients for definitive inclusion.Mean age was 75.7 ± 14.8 years old, 498 (45%) patients had PR AKI and 605 (55%) I AKI. BCR was 90.55 ± 39.32 and 91.29 ± 39.79 in PR AKI and I AKI groups respectively. There was no statistical difference between mean BCR of the PR AKI and I AKI groups, p = 0.758. The area under the ROC curve was 0.5 indicating that BCR had no capacity to discriminate between PR AKI and I AKI.ConclusionsOur study is the largest to investigate the diagnostic performance of BCR. BCR is not a reliable parameter for distinguishing prerenal AKI from intrinsic AKI.

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“…The BCR is one of the diagnostic tools recommended to ED physicians for differentiating between PR and I AKI, yet it has never been specifically studied in this setting [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic performance of serum blood urea nitrogen to creatinine ratio for distinguishing prerenal from intrinsic acute kidney injury in the emergency department

et al. 2017

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show abstract

“…Although the mean BUN values differed significantly ( P = 0.002) between the 2 groups, no difference was observed between the creatinine values. In addition, BUN: creatinine ratio (BCR) is a recommended tool for the diagnosis of acute kidney injury (3). BCR could be applied to define organ dysfunction in acute pancreatitis severity classification.…”

mentioning

confidence: 99%