Renal Excretion of Water and Solutes During the Normal Menstrual Cycle

Parboosingh, J.; Doig, A.; Michie, Eileen A.

doi:10.1111/j.1471-0528.1973.tb02960.x

BJOG

1973

DOI: 10.1111/j.1471-0528.1973.tb02960.x

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Renal Excretion of Water and Solutes During the Normal Menstrual Cycle

J. Parboosingh¹,

A. Doig

Eileen A. Michie³

Abstract: Mean urine flow and the urinary excretion of total solute, sodium, potassium and urea were measured continuously throughout one menstrual cycle in nine healthy women on an unrestricted diet. The results obtained in the first and second halves of the cycle were compared in respect of 24 hour, day and night periods. The greatest differences occurred between the ovulatory and the early luteal phases, there being a significant increase after ovulation in mean 24 hour urine flow and the excretion of total solute, s… Show more

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Cited by 4 publications

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“…The luteal rise can be attributed to sodium loss induced by progesterone but the rise near ovulation is less easily explained [Sundsfjord and Askvaag, 1973]. Such questions have practical significance since the aetiology of both premenstrual tension and contraceptive hypertension remain uncertain [Edwards and Baylis, 1973;Laragh, Newton, Sealey and Ledingham, 1969;Morton, 1950;Parboosingh, Doig and Mickie, 1973;Phillips, McCoord and Pommerenke, 1952].…”

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confidence: 99%

Water and Electrolyte Excretion During the Oestrous Cycle in Sheep

Michell

1979

Exp Physiol

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Electrolyte excretion was observed during 24 oestrous cycles in housed sheep, together with mixed salivary Na/K ratio during 10 additional cycles. 1. The sharp fall in food and fluid intake at oestrus accompanied a peak of sodium excretion which changed to peak retention 3 days later, both in faeces and urine. 2. Potassium excretion declined with food intake at oestrus but subsequently failed to recover to pre-oestrous levels dispite full recovery of dietary intake. 3. Curiously, water intake also recovered completely whereas urinary and faecal water retention continued; faecal loss actually exceeded renal excretion on these liberal water intakes. 4. Changes in salivary, urinary and faecal Na/K indicated an aldosterone peak neither during the luteal phase nor at oestrus but three days later. The data rarse questions concerning the regulation of water and electrolyte balance within the normal cycle. They also provide a baseline for the investigation of renal effects of gonadal steroids. Possible roles for aldosterone, ADH and progesterone in maintaining fluid and electrolyte balance are discussed, emphasising problems confronting species which have evolved with heavy obligatory potassium excretion but undependable supplies of sodium and water.Sheep vary their sodium intake during the oestrous cycle, taking least at oestrus and most at the climax of the luteal phase [Michell, 1975]. This seemed consistent with the idea that oestrogens stimulate salt retention whereas progesterone promotes natriuresis [Landau, 1973], but specific data in sheep were lacking.Salt retaining effects of oestrogens were suspected almost as soon as those of adrenal steroids [Thorn, Nelson and Thorn, 1938] but considerable conflict emerges from the literature on gonadal steroids and electrolyte excretion [Christy and Shaver, 1974;Lindheimer and Katz, 1977]. The factors influencing aldosterone levels during the human cycle remain uncertain [Schwartz, 1975]. The luteal rise can be attributed to sodium loss induced by progesterone but the rise near ovulation is less easily explained [Sundsfjord and Askvaag, 1973]. Such questions have practical significance since the aetiology of both premenstrual tension and contraceptive hypertension remain uncertain

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Water and Electrolyte Excretion During the Oestrous Cycle in Sheep

Michell

1979

Exp Physiol

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Renal segmental tubular response to salt during the normal menstrual cycle

Péchère-Bertschi¹,

Maillard²,

Stalder³

et al. 2002

Kidney International

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Changes in Renal Water and Electrolyte Excretion Occurring Before and After Induced Ovulation and Their Relation to Total Oestrogen and Pregnanediol Excretion

Parboosingh

Doig

Michie

1974

BJOG

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Summary Ovulation was induced by gonadotrophin therapy in eight women with secondary amenorrhoea. During ovarian inactivity and throughout the preovulatory and luteal phases of the induced cycles continuous measurements were made of mean urine flow and the urinary excretion of total solute, sodium, potassium, urea, total oestrogens and pregnanediol. The preovulatory rise in total oestrogen excretion was associated with a reduction in sodium output whereas the excretion of greatly increased amounts of pregnanediol after ovulation was associated with an increase in sodium excretion. Maximal pregnanediol excretion tended to coincide with a second peak in total oestrogen excretion but was unaccompanied by any further rise in sodium output. Night sodium excretion was disproportionately increased after ovulation and was associated with an increment in night potassium excretion. Alterations observed in total solute excretion and urine flow were mainly determined by changes in sodium excretion.

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Renal Excretion of Water and Solutes During the Normal Menstrual Cycle

Cited by 4 publications

References 23 publications

Water and Electrolyte Excretion During the Oestrous Cycle in Sheep

Water and Electrolyte Excretion During the Oestrous Cycle in Sheep

Renal segmental tubular response to salt during the normal menstrual cycle

Changes in Renal Water and Electrolyte Excretion Occurring Before and After Induced Ovulation and Their Relation to Total Oestrogen and Pregnanediol Excretion

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