Renal effects of aluminium in uraemic rats and in rats with intact kidney function

Abstract

The effect on renal function following administration of aluminium (i.p., five times weekly (0.05 or 0.5 mg kg-1 body weight) for 12 weeks) to partially nephrectomized (5/6 NX) or intact female rats was examined. The observed loss of concentrating ability, characterized by increased urine volume and an increased sodium excretion, as well as increased renal excretion of p-aminohippurate (demonstrable after low-dose treatment with nephrotoxins) can be interpreted as an initiation of kidney function injury. No distinct differences in response were observed between partially nephrectomized and intact animals.

Tissue Aluminum Accumulation and Toxic Consequences in Rats Chronically Fed Aluminum with and without Citrate

“…Less has been published on the effects of aluminum accumulation on kidney function. Previously, Ecelbarger and Greger (1991) and Braunlich et al (1986) have observed decreased kidney function in rats injected with aluminum.…”

Renal handling of amino acids in 5/6-nephrectomized rats: Stimulation of renal amino acid reabsorption after treatment with triiodothyronine or dexamethasone under amino acid load

“…Bleeding was prevented using tissue adhesive (Histoacryl blau °, B. Braun, Melsungen, Germany). Three days later the right kidney was removed (see Brfiunlich et al, 1986). Clearance experiments were done six days after the first operation.…”

Relationship of a Novel c.429delC Deletion in Hairless Gene HR with Alopecia in Two Families from Southern Punjab, Pakistan

“…Certain diseases enhance the absorption of Al through the gastrointestinal tract. For example, patients of chronic renal insufficiency or uremia have been reported to absorb Al more readily than normal individuals (Braunlich et al, 2006).…”