Abstract:Lopinavir/ritonavir and sulfamethoxazole/ trimethoprim have been individually associated with renal adverse events which could be characterized by electrolyte imbalance. The concurrent use of these drugs in the management of HIV and co infections may impair renal function; therefore this work evaluates the renal effect of the co administration of these drugs in rats. Seventy five (75) animals which were divided into five (5) groups were used in this study. Group A which served as control contained fifteen (15)… Show more
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