Renal dysfunction in liver cirrhosis: Renal duplex doppler US vs. Scintigraphy for early identification

Alkareemy, Enas Ahmed Reda; Sobh, Mohamed; Anees, Muhammad; Mostafa, Mohamed; Saber, Rafet A

doi:10.1016/s0009-9260(98)80033-0

Cited by 12 publications

(4 citation statements)

References 8 publications

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“…Comparison of our results with those obtained by using the standard method of renal perfusion scintigraphy revealed a very good correlation. This sustains the data obtained in adults by Al-Kareemy et al [14], Bair et al [15], and Terry et al [16]who showed that color Doppler ultrasound represents a sensitive procedure in assessing the renal function. Beyond that, we established this method in children with VUR for the first time.…”

Section: Discussionsupporting

confidence: 90%

Importance of the Renal Resistive Index in Children Suffering from Vesicoureteral Reflux

Radmayr¹,

Klauser

Maneschg³

et al. 1999

European Urology

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Section: Discussionsupporting

confidence: 90%

Importance of the Renal Resistive Index in Children Suffering from Vesicoureteral Reflux

Radmayr¹,

Klauser

Maneschg³

et al. 1999

European Urology

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“…In the future, attempts should be made to correlate non invasive biomarkers of kidney damage [94][95][96] to pathological findings. The potential contribution of renal artery Doppler ultrasonography in the detection of early increase in vascular resistance should be further investigated [50,97]. At present, accurate assessment of renal function and lesions in cirrhotic patients is necessarily costly, time consuming and invasive.…”

Section: Acute Renal Failurementioning

confidence: 99%

The evaluation of renal function and disease in patients with cirrhosis

Francoz

Glotz

Moreau

et al. 2010

Journal of Hepatology

224

206

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The MELD score has shown that, besides markers of liver function, serum creatinine has a strong prognostic value in cirrhosis. However, even though creatinine has a good prognostic value, it is an inaccurate marker of renal function in cirrhosis. Creatinine and creatinine-based equations tend to overestimate glomerular filtration rate (GFR), and creatinine clearance from timed urine collection also overestimates GFR. Hence, clearance of exogenous markers such as iohexol remains the only reliable method for assessing precisely GFR in cirrhosis. Whereas these investigations are limited by their costs and complexity, and they can hardly be repeated at short intervals, serum cystatin C could be an alternative, although it needs further validation. Accurate markers and/or specific equations are therefore still needed to assess GFR in cirrhotic patients. Pre-renal failure and hepatorenal syndrome (HRS) are the main causes of acute renal failure in cirrhosis. Both result from decreased renal blood flow and both can result in acute tubular necrosis. HRS is not always fully reversible with liver transplantation possibly due to underlying chronic kidney damage. A number of cirrhotic patients with acute renal failure may also have chronic kidney damage ("acute-on-chronic renal failure"); furthermore, cirrhotic patients frequently have co-morbidities such as diabetes that may result in chronic impairment in renal function. Since conventional urinary markers are biased in cirrhosis, a biopsy is the only way to document and quantify renal lesions; moreover, transvenous route should be preferred to percutaneous route. In candidates for transplantation, attention should therefore be focused on vascular lesions which may represent a risk factor for nephrotoxicities induced by calcineurin-inhibitors.

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“…Nephrotoxicity is one of the most common adverse drug reactions (6.8%), and most adverse drug reactions occur in patients with advanced cirrhosis (Child-Pugh C), often with renal impairment [ 5 ]. Another aspect to highlight is that patients with cirrhosis have reduced effective renal plasma flow and glomerular filtration rates, even in the absence of ascites [ 126 , 127 ]. Moreover, patients with liver cirrhosis have low serum creatinine concentrations (due to impaired synthesis of creatinine and reduced muscle mass), which may indicate that actual glomerular filtration rates cannot be estimated from serum creatinine levels [ 128 , 129 ].…”

Section: Renal Impairmentmentioning

confidence: 99%

Antibiotics and Liver Cirrhosis: What the Physicians Need to Know

et al. 2021

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The liver is the primary site of drug metabolism, which can be altered by a variety of diseases affecting the liver parenchyma, especially in patients with liver cirrhosis. The use of antibiotics in patients with cirrhosis is usually a matter of concern for physicians, given the lack of practical knowledge for drug choice and eventual dose adjustments in several clinical scenarios. The aim of the current narrative review is to report, as broadly as possible, basic, and practical knowledge that any physician should have when approaching a patient with liver cirrhosis and an ongoing infection to efficiently choose the best antibiotic therapy.

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Renal dysfunction in liver cirrhosis: Renal duplex doppler US vs. Scintigraphy for early identification

Cited by 12 publications

References 8 publications

Importance of the Renal Resistive Index in Children Suffering from Vesicoureteral Reflux

Importance of the Renal Resistive Index in Children Suffering from Vesicoureteral Reflux

The evaluation of renal function and disease in patients with cirrhosis

Antibiotics and Liver Cirrhosis: What the Physicians Need to Know

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