Renal Dysfunction and Inflammatory Markers in Hypertensive Patients seen in a University Hospital

Braga, Fátima; Arruda, Ilma Kruze Grande de; Diniz, Alcides da Silva; Cabral, Poliana Coelho; Lemos, Manoel; Braga, Marcus Davis Machado; Júnior, Hilton de Castro Chaves

doi:10.5935/abc.20130102

Cited by 5 publications

(2 citation statements)

References 23 publications

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“…Participants were categorized according to the presence of low-grade inflammation based on the hs-CRP value, a gold-standard method for the detection of inflammation. As the cutoff point for hs-CRP, participants with no inflammation were those who obtained a result <0.5 mg/dL [ 25 ].…”

Section: Methodsmentioning

confidence: 99%

Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Nondialysis Chronic Kidney Patients

Brito

Fontenele

Carneiro

et al. 2021

International Journal of Inflammation

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Background. The Neutrophil-to-Lymphocyte Ratio (NLR) and the Platelet-to-Lymphocyte Ratio (PLR) are inflammatory biomarkers for several diseases, such as cancer and cardiovascular morbidities; however, there are currently few studies on kidney diseases. We aimed to evaluate nondialysis patients and determine the association of NLR and PLR with inflammation in these patients. Methods. A prospective cross-sectional study was conducted with 85 patients at different stages of chronic kidney disease (CKD), treated at the Kidney Disease Prevention Center of the University Hospital of the Federal University of Maranhão. This study included adult nondialysis patients diagnosed with CKD. The participants’ blood samples were collected for a high-sensitivity C-reactive protein (hs-CRP) test and blood count. They were divided into two groups according to the presence or absence of inflammation based on the hs-CRP value (<0.5 mg/dL). NLR and PLR were calculated based on the absolute number of neutrophils, lymphocytes, and platelets and were compared between them and with hs-CRP. Statistical analysis was performed using the Stata software, with the Shapiro–Wilk, Mann–Whitney, Spearman’s Correlation, and receiver operating characteristic curve tests. This study was approved by the local ethics committee. Results. The participants were categorized into two groups: with inflammation (n = 64) and without inflammation (n = 21). The mean age was 61.43 ± 14.63 y. The NLR and PLR values were significantly different between the groups with and without inflammation ( p = 0.045 and p = 0.004 , respectively). However, only PLR showed a significant positive correlation with hs-CRP ( p = 0.015 ). The best cutoff point for NLR to detect inflammation was 1.98, with 76.19% sensitivity and 48.44% specificity. For PLR, it was 116.07, with 85.71% sensitivity and 51.56% specificity. There was no significant difference between the area under the NLR and PLR curve (0.71 vs. 0.64; p = 0.186 ) for this population. Conclusions. This study showed that PLR was positively correlated with hs-CRP in nondialysis CKD patients and can be used to identify inflammation in this population.

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Section: Methodsmentioning

confidence: 99%

Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Nondialysis Chronic Kidney Patients

Brito

Fontenele

Carneiro

et al. 2021

International Journal of Inflammation

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“…Dentre esse conjunto de doenças denominadas crônicas não-transmissíveis, encontra-se a Doença Renal Crônica (DRC), considerada a nova epidemia do século XXI, uma síndrome clínica que caracteriza-se pela redução significativa, lenta, gradual e progressiva das funções renais excretoras, endócrinas e metabólicas. Sua incidência vem aumentando e apresenta elevados índices de morbimortalidade mesmo na fase pré-dialítica 4,5 .…”

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Perfil De Pacientes Hemodialíticos Relacionados a Parâmetros Bioquímicos E Hematológicos No Oeste Catarinense

et al. 2017

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Este estudo teve o objetivo de analisar a adequação sanitária de um serviço de hemodiálise (HD) no oeste catarinense, no decorrer de 2014, relacionando-a aos parâmetros bioquímicos, hematológicos apresentados pelos pacientes hemodialítico e o trabalho da equipe de enfermagem. Pesquisa de caráter observacional, exploratória, transversal com amostragem sistemática aleatória. Foram encontradas alterações nos parâmetros bioquímicos e hematológicos referentes ao Grupo 1 (3-7 meses de HD) em relação a outros três Grupos (8-12, 13-24 e 25-36 meses de HD). Alterações nos parâmetros bioquímicos e hematológicos estão presentes em pacientes hemodialíticos, especialmente no que se refere aos biomarcadores inflamatórios, refletindo maior fragilidade imunológica. Tais parâmetros são ferramentas para avaliar a qualidade e efetividade da terapia de hemodiálise, assim como o acompanhamento do enfermeiro durante as seções de hemodiálise na evolução clínica do paciente. Palavras-chave: rim, hemodiálise, doença renal crônica, vigilância sanitária.

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Biophysical integrated approach for the management of early stages of CKD in elderly patients: a 12-month controlled study

2019

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Renal Dysfunction and Inflammatory Markers in Hypertensive Patients seen in a University Hospital

Abstract: The results show an association of inflammatory activity and metabolic syndrome with renal function deficit.

Cited by 5 publications

References 23 publications

Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Nondialysis Chronic Kidney Patients

Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Nondialysis Chronic Kidney Patients

Perfil De Pacientes Hemodialíticos Relacionados a Parâmetros Bioquímicos E Hematológicos No Oeste Catarinense

Biophysical integrated approach for the management of early stages of CKD in elderly patients: a 12-month controlled study

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