Biology and Management of Multiple Myeloma 2004
DOI: 10.1007/978-1-59259-817-5_14
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Renal Diseases Associated With Multiple Myeloma and Related Plasma Cell Dyscrasias

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Cited by 2 publications
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“…Anemia in MM is associated with inadequate erythropoietin production and responsiveness, decreased red blood cell lifespan, and incorrect release of iron from macrophages (normal to high iron stores with low serum iron) (Ludwig & Osterborg, 2010). Renal disease in MM is associated with the immunoglobulin products (M proteins) of monoclonal plasma cells in the bone marrow, which form kidney deposits typically progressing to renal tubular, glomerular, and vascular pathology and failure (Soloman, Weiss, & Herrera, 2010). Those disease-related factors may predispose patients with MM to develop secondary sleep disorders such as RLS and PLMs.…”
mentioning
confidence: 99%
“…Anemia in MM is associated with inadequate erythropoietin production and responsiveness, decreased red blood cell lifespan, and incorrect release of iron from macrophages (normal to high iron stores with low serum iron) (Ludwig & Osterborg, 2010). Renal disease in MM is associated with the immunoglobulin products (M proteins) of monoclonal plasma cells in the bone marrow, which form kidney deposits typically progressing to renal tubular, glomerular, and vascular pathology and failure (Soloman, Weiss, & Herrera, 2010). Those disease-related factors may predispose patients with MM to develop secondary sleep disorders such as RLS and PLMs.…”
mentioning
confidence: 99%
“…The deposition of these components as renal tubular casts, peritubular deposits, or amyloid fibrils leads to organ dysfunction, resulting in considerable morbidity and, eventually, death 2. Thus, the ability to measure accurately serum or urinary FLC concentrations in these patients, as well as identify by immunochemical means the clonal nature of bone marrow derived plasma cell populations and pathologic tissue deposits, has diagnostic, therapeutic, and prognostic import.…”
mentioning
confidence: 99%