Renal diseases associated with multiple sclerosis: A narrative review

Abstract

The mechanisms of renal pathology in multiple sclerosis (MS) can be related to the disease itself or its treatment. Although kidney disease can be associated with MS, not much has been reported in the literature; hence, our study aimed to describe the prevalence and types of renal diseases and discuss their prognosis in patients with MS. A literature search (2012-2022) was performed using the Scale for the Assessment of Narrative Review Articles. The databases searched included MEDLINE (PubMed) and EMBASE. Fourteen articles from these databases met the inclusion criteria. The inclusion criteria were as follows: publications with full-text access. Articles published in English. Original articles related to renal diseases in MS. The prevalence of renal diseases in MS from the articles obtained ranged from 0.74% to 2.49%. Interferon beta (IFN-β)-associated glomerulonephritis was common among the reviewed articles. Significant improvement and resolution of the pathology were observed after the discontinuation of the offending medication. Renal symptoms in 2 out of 4 cases with renal thrombotic microangiopathy (TMA) induced by interferon-beta progressed to chronic kidney disease, even after the drug was stopped. Other studied renal pathologies included nephrolithiasis secondary to urinary retention and urinary catheter use in patients with MS.

Renal disease associated with multiple sclerosis: A narrative review

“…Furthermore, shared genetic susceptibility between MS and certain renal conditions raises intriguing questions about the existence of common underlying genetic factors. [ 5 ] Exploring the genetic landscape of both disorders may unveil novel insights into their co-occurrence and inform targeted therapeutic strategies.…”

“…Some disease-modifying therapies (DMTs) used in managing MS, such as interferons and monoclonal antibodies, may have nephrotoxic effects or affect renal function, potentially contributing to renal complications. [5] www.md-journal.com…”

“…This can impact their ability to access necessary care and maintain their overall QOL. [5] 5.5.6. Patient perspectives.…”

“…Fluid balance disturbances, influenced by neurogenic bladder dysfunction, can contribute to hypertension and impact renal function. [5] Edema and fluid retention. Renal dysfunction in MS may lead to fluid retention and edema, presenting as peripheral swelling.…”

“…We delve into the intricate corridors of MS and renal disease, guided by the notion that their connection holds profound implications for the individuals navigating the complex landscape of chronic illness. [ 5 ] By immersing ourselves in the evolving narrative of this association, we aim to foster a deeper understanding that transcends the limitations of compartmentalized medical perspectives.…”