Renal disease in women with severe preeclampsia or gestational proteinuria

Abstract

Women who had gestational proteinuria or preeclampsia before 30 weeks' gestation were more likely to have had underlying renal disease.

Long term effects of gestational hypertension and pre-eclampsia on kidney function: Record linkage study

“…Most studies have used microalbuminuria as the outcome measure, both as continuous as well as a dichotomous variable. There were less consistent associations observed between PE and higher levels of protein in the urine (proteinuria: >300 mg/24 h of protein detected in urine), abnormal biochemistry blood tests (elevated creatinine or reduced glomerular filtration rate (GFR)), abnormal renal biopsy or end stage renal disease (ESRD) [7], [8], [9], [13] . The largest, and most recently published study [9], used record linkage of the Norwegian Birth and Renal Registries to study the association of PE with Renal Replacement Therapy (RRT).…”

“…There was, however, no difference in terms of serum creatinine levels and estimated Glomerular Filtration Rate (eGFR) between women with preeclampsia and those without. An updated search of the literature identified three additional papers [7], [8], [9] all reporting a positive association between preeclampsia and long term kidney damage, although heterogeneity in terms of exposure and outcome measurement remained as did the possibility of publication bias. In their review, McDonald et al [6] called for further research investigating the persistence of microalbuminuria following preeclampsia in larger population based studies, taking into consideration confounding factors such as age, BMI, smoking etc.…”

Pregnancy, delivery and perinatal outcome in female survivors of polio

“…Similar to preeclampsia, renal dysfunction may present with high blood pressure, proteinuria, and edema. A clinical distinction between pre-eclampsia and renal disease is difficult, especially if the latter is precipitated during pregnancy [25]. Pre-eclampsia was significantly more frequent in the polio group, irrespective of maternal age and parity.…”

Steroid Pulse Therapy for De Novo Minimal Change Disease During Pregnancy

“…A previous observational study concluded that gestational proteinuria is a risk factor in pre-eclampsia and precedes hypertension in 20% of patients with pre-eclampsia; [3] however, Murakami et al reported that women who had proteinuria prior to 30 weeks of gestation were more likely to have had underlying renal disease [4]. Nephrotic syndrome is specifically defined by the presence of severe proteinuria (>3.5 g/24 h), hypoalbuminemia (<3 g/dL), and peripheral edema.…”